Application and efficacy of quetiapine in patients with high-risk factors for bipolar disorder: A randomized controlled trial

Table 1 Comparison of the Hamilton anxiety scale score (mean ± SD)

	Baseline	1 week	2 weeks	4 weeks	8 weeks	16 weeks	24 weeks
A group	22.31 ± 2.49	16.31 ± 3.34	11.47 ± 3.44	7.84 ± 3.85	6.00 ± 3.47	4.94 ± 2.66	5.44 ± 3.13
B group	22.18 ± 2.87	13.09 ± 3.15	9.79 ± 4.34	6.15 ± 4.24	4.76 ± 3.90	3.97 ± 3.10	3.79 ± 3.36
t value	0.196	4.007	1.729	1.683	1.355	1.349	2.046
P value	0.845	< 0.001	0.089	0.097	0.180	0.182	0.045

Table 2 Comparison of the Hamilton depression scale score (mean ± SD)

	Baseline	1 week	2 weeks	4 weeks	8 weeks	16 weeks	24 weeks
A group	12.97 ± 2.50	8.44 ± 2.79	5.44 ± 3.48	4.28 ± 2.67	3.41 ± 2.09	2.91 ± 1.61	2.81 ± 1.66
B group	13.33 ± 2.29	6.64 ± 2.00	3.42 ± 2.68	3.45 ± 2.86	2.79 ± 2.22	2.48 ± 1.79	2.45 ± 1.89
t value	-0.614	2.998	2.617	1.204	1.155	0.997	0.812
P value	0.541	0.004	0.011	0.233	0.252	0.323	0.420

Table 3 Comparison of the Bech-Rafaelsen Mania scale score (mean ± SD)

	Baseline	1 week	2 weeks	4 weeks	8 weeks	16 weeks	24 weeks
A group	3.59 ± 2.86	1.09 ± 1.69	0.28 ± 0.58	0.16 ± 0.45	0.16 ± 0.57	0.16 ± 0.44	0.31 ± 0.93
B group	3.15 ± 2.86	1.18 ± 1.55	0.33 ± 0.85	0.15 ± 0.44	0.06 ± 0.24	0.03 ± 0.17	0.15 ± 0.57
t value	0.623	-0.219	-0.287	0.043	0.880	1.503	0.845
P value	0.536	0.827	0.775	0.966	0.382	0.138	0.401