Clinical Trials Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2017; 8(5): 213-221
Published online May 15, 2017. doi: 10.4239/wjd.v8.i5.213
Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, M G Joseraj, Chandni Radhakrishnan
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, Department of Periodontics, Government Dental College, Calicut 673008, Kerala, India
M G Joseraj, Department of Biochemistry, Government Medical College, Calicut 673008, Kerala, India
Chandni Radhakrishnan, Department of Internal Medicine, Government Medical College, Calicut 673008, Kerala, India
Author contributions: Joseph R has contributed to conception, study design, data analysis, intellectual content, interpretation of data and final approval of the manuscript; Sasikumar M has contributed to study design, data analysis, interpretation of data and manuscript drafting; Radhakrishnan C has contributed to study design, interpretation of data, intellectual content and final approval of the manuscript; Mammen J has contributed to data analysis, drafting and editing of the manuscript and language revision; Joseraj MG has contributed to acquisition, study design, interpretation of data and final approval of the manuscript; all authors approved the final version to be published.
Institutional review board statement: The study was reviewed and approved by the Institutional ethics committee, Government Dental College, Kozhikode on 13-12-2013 (IEC NO 27/2013).
Informed consent statement: All the study participants were explained about the study and informed written consent was obtained prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest in this study. This study was supported by personnel funds of the authors.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Rosamma Joseph, Professor and Head, Department of Periodontics, Government Dental College, Medical College Campus, Calicut 673008, Kerala, India. drrosammajoseph@gmail.com
Telephone: +91-944-6070599 Fax: +91-495-2356781
Received: November 24, 2016
Peer-review started: November 27, 2016
First decision: January 16, 2017
Revised: February 25, 2017
Accepted: March 12, 2017
Article in press: March 13, 2017
Published online: May 15, 2017
Core Tip

Core tip: A bidirectional link exists between diabetes and periodontitis. Periodontitis may affect glycemic control in otherwise systemically healthy individuals resulting in an elevated glycosylated hemoglobin level. Pre diabetes may be associated with periodontal disease in systemically healthy subjects. This clinical trial evaluated the effect of non-surgical periodontal therapy on glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). This study showed that periodontal therapy improved periodontal health status and decreased glycosylated hemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP.