Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2022; 13(11): 949-961
Published online Nov 15, 2022. doi: 10.4239/wjd.v13.i11.949
Published online Nov 15, 2022. doi: 10.4239/wjd.v13.i11.949
Combination therapy of hydrogel and stem cells for diabetic wound healing
Jia-Na Huang, Hao Cao, Kai-Ying Liang, Yan Li, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Jia-Na Huang, Hao Cao, Kai-Ying Liang, Yan Li, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, China
Li-Ping Cui, Endocrinology Department, Panyu Central Hospital, Guangzhou 511400, Guangdong Province, China
Author contributions: Li Y designed the research study; Huang JN and Cao H searched the literature and drafted the initial manuscript; Liang KY and Cui LP provided further revision; all authors have read and approved the final version of the manuscript.
Supported by the Shenzhen Basic Research Project , No. JCYJ20190807155805818 ; and the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument , No. 2020B1212060077 .
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Li, PhD, Associate Professor, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, No. 66 Gongchang Road, Shenzhen 518107, Guangdong Province, China. liyan99@mail.sysu.edu.cn
Received: August 28, 2022
Peer-review started: August 28, 2022
First decision: September 12, 2022
Revised: September 25, 2022
Accepted: November 2, 2022
Article in press: November 2, 2022
Published online: November 15, 2022
Peer-review started: August 28, 2022
First decision: September 12, 2022
Revised: September 25, 2022
Accepted: November 2, 2022
Article in press: November 2, 2022
Published online: November 15, 2022
Core Tip
Core Tip: Diabetic wounds are a common diabetes mellitus complication with a low cure rate and likely recurrence. Although stem cell therapy is suitable for diabetic wound healing, simple transplantation methods, such as intravenous, subcutaneous, intramuscular, and local injection, are not conducive to cell survival, thus resulting in compromised efficacy. To improve the outcome of stem cell therapy, researchers have designed different types of hydrogels for stem cell delivery to ensure cell viability and paracrine functions. Herein, we discuss the current roles and applications of hydrogel and stem cell combination therapy for diabetic wound treatment.