Lacerda DC, Trindade da Costa PC, Pontes PB, Carneiro dos Santos LA, Cruz Neto JPR, Silva Luis CC, de Sousa Brito VP, de Brito Alves JL. Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review. World J Diabetes 2022; 13(9): 717-728 [PMID: 36188141 DOI: 10.4239/wjd.v13.i9.717]
Corresponding Author of This Article
José Luiz de Brito Alves, PhD, Adjunct Professor, Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Rue Francisco Carneiro de Araújo, n 55, apt 403, João Pessoa 58045-190, Paraíba, Brazil. jose_luiz_61@hotmail.com
Research Domain of This Article
Microbiology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Sep 15, 2022; 13(9): 717-728 Published online Sep 15, 2022. doi: 10.4239/wjd.v13.i9.717
Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review
Diego Cabral Lacerda, Paulo César Trindade da Costa, Paula Brielle Pontes, Lucas Alves Carneiro dos Santos, José Patrocínio Ribeiro Cruz Neto, Cristiane Cosmo Silva Luis, Vanessa Polyana de Sousa Brito, José Luiz de Brito Alves
Diego Cabral Lacerda, Paulo César Trindade da Costa, Lucas Alves Carneiro dos Santos, José Patrocínio Ribeiro Cruz Neto, Cristiane Cosmo Silva Luis, Vanessa Polyana de Sousa Brito, Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, 58051-900, Paraíba, Brazil
Paula Brielle Pontes, Department of Neuropsychiatry, Health Sciences Center, Federal University of Pernambuco, Recife, 50670-901, Pernambuco, Brazil
José Luiz de Brito Alves, Department of Nutrition, Federal University of Paraíba, João Pessoa, 58045-190, Paraíba, Brazil
Author contributions: de Brito Alves JL contributed to the conceptualization; Lacerda DC, Trindade da Costa PC, Pontes PB, Carneiro dos Santos LA, Cruz Neto JP, Silva Luis CC, de Sousa Brito VP, de Brito Alves JL wrote, reviewed and edited the manuscript.
Conflict-of-interest statement: The authors declare no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: José Luiz de Brito Alves, PhD, Adjunct Professor, Department of Nutrition, Health Sciences Center, Federal University of Paraíba, Rue Francisco Carneiro de Araújo, n 55, apt 403, João Pessoa 58045-190, Paraíba, Brazil. jose_luiz_61@hotmail.com
Received: March 2, 2022 Peer-review started: March 2, 2022 First decision: April 17, 2022 Revised: April 29, 2022 Accepted: August 14, 2022 Article in press: August 14, 2022 Published online: September 15, 2022
Abstract
Oxidative stress, inflammation, and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus. Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years. Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress, inflammation, and diabetes mellitus. Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system, resulting in the amelioration of glucose homeostasis in diabetic conditions. This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties, their sources, range of dosage, and the intervention time in experiments with animals and clinical trials. This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits.
Core Tip: This review strives to serve as a relevant and well-cataloged reference of L. fermentum strains with aptitudes of inducing anti-diabetic effects and health-promoting benefits to the host envisaging their wide applicability to diabetes control.
