Da Porto A, Miranda C, Brosolo G, Zanette G, Michelli A, Ros RD. Nutritional supplementation on wound healing in diabetic foot: What is known and what is new? World J Diabetes 2022; 13(11): 940-948 [PMID: 36437863 DOI: 10.4239/wjd.v13.i11.940]
Corresponding Author of This Article
Andrea Da Porto, MD, MSc, Doctor, Department on Internal Medicine, University of Udine, Via Colugna, Udine 33100, Italy. daporto.andrea@gmail.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Nov 15, 2022; 13(11): 940-948 Published online Nov 15, 2022. doi: 10.4239/wjd.v13.i11.940
Nutritional supplementation on wound healing in diabetic foot: What is known and what is new?
Andrea Da Porto, Cesare Miranda, Gabriele Brosolo, Giorgio Zanette, Andrea Michelli, Roberto Da Ros
Andrea Da Porto, Gabriele Brosolo, Department on Internal Medicine, University of Udine, Udine 33100, Italy
Cesare Miranda, Giorgio Zanette, Department of Internal Medicine, Clinic of Endocrinology and Metabolism Diseases Azienda Sanitaria Friuli Occidentale, Pordenone 33170, Italy
Andrea Michelli, Roberto Da Ros, Department of Internal Medicine , SC Diabete e Centro Trattamento Piede Diabetico, Monfalcone 34074, Gorizia, Italy
Author contributions: Da Porto A and Miranda C came up with ideas and constructs; Da Porto A, Miranda C, and Da Ros R wrote the manuscript; Michelli A, Brosolo G, and Zanette G approved the main conceptual ideas and made corrections; all authors provided final edits and approved the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrea Da Porto, MD, MSc, Doctor, Department on Internal Medicine, University of Udine, Via Colugna, Udine 33100, Italy. daporto.andrea@gmail.com
Received: August 11, 2022 Peer-review started: August 11, 2022 First decision: September 4, 2022 Revised: September 13, 2022 Accepted: October 11, 2022 Article in press: October 11, 2022 Published online: November 15, 2022
Abstract
Non-healing diabetic foot ulcers (DFU) are the most notable and striking complications of diabetes mellitus. More than 25% of nonhealing DFU can ultimately lead to amputation of the lower extremity within 6-18 mo after the first manifestation of the wound. Although wound healing is complex, nutritional status is crucial in soft tissue repair. Malnutrition is highly prevalent and overlooked in patients with diabetes and chronic wounds. Moreover, to date, we do not have clear recommendations or evidence about the use of nutritional supplements for improving wound healing in patients with DFU. In this article the authors briefly analyzed the current evidence on the use of nutritional supplements of proteins or amino acids, fatty acids, probiotics, vitamins, and trace elements in the wound healing process in patients with DFU.
Core Tip: Malnutrition is common in patients with diabetes and chronic wounds. To date we do not have clear recommendations or evidence about the use of nutritional supplements for improving wound healing in patients with diabetic foot ulcers (DFU). This paper aimed to evaluate current evidence regarding the use of Nutritional supplementation on wound healing in patients with DFU.
