Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2088-2100
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2088
Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer
Mitsuru Sugimoto, Kazumichi Abe, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi, Hiromasa Ohira
Mitsuru Sugimoto, Kazumichi Abe, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Hiromasa Ohira, Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi, Department of Endoscopy, Fukushima Medical University Hospital, Fukushima 960-1295, Japan
Author contributions: Sugimoto M wrote the paper and designed and performed the research and laboratory experiments; Abe K provided advice on the laboratory experiments and research; Takagi T, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Watanabe K, Nakamura J, Kikuchi H, Takasumi M, Hashimoto M, Kato T, and Kobashi R provided clinical advice; Hikichi T supervised the report; Ohira H supervised the report and writing of the paper.
Institutional review board statement: This study was approved by the Institutional Review Board of Fukushima Medical University (Approval No. 2451).
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The datasets analyzed during the current study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mitsuru Sugimoto, MD, PhD, Assistant Professor, Doctor, Department of Gastroenterology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. kitachuuou335@yahoo.co.jp
Received: March 22, 2021
Peer-review started: March 22, 2021
First decision: July 3, 2021
Revised: July 10, 2021
Accepted: September 16, 2021
Article in press: September 16, 2021
Published online: December 15, 2021
Core Tip

Core Tip: Recently, a correlation between the human microbiota and malignant gastrointestinal diseases was reported. In this report, the efficacy of the duodenal microbiota for diagnosing pancreaticobiliary cancer (PB Ca) was investigated. The combination of Clostridium cluster XVIII (cutoff value: 3.038%) and cancer antigen 19-9 Levels (cutoff value: 18.8 U/mL) showed 91.7% sensitivity and 71.4% specificity for diagnosing PB Ca. In conclusion, the duodenal microbiota may be useful for PB Ca screening.