Enomoto H, Nakamura H, Komatsu-Kanatani N, Liu Y, Yoshida K, Okuda Y, Yamamoto T, Liu W, Nishiguchi S. Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice. World J Hepatol 2009; 1(1): 98-102 [PMID: 21160971 DOI: 10.4254/wjh.v1.i1.98]
Corresponding Author of This Article
Hideji Nakamura, MD, PhD, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan. nakamura@hyo-med.ac.jp
Article-Type of This Article
Brief Article
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Hirayuki Enomoto, Hideji Nakamura, Teruhisa Yamamoto, Weidong Liu, Shuhei Nishiguchi, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan
Naoko Komatsu-Kanatani, Yu Liu, Kenya Yoshida, Yorihide Okuda, Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
Author contributions: Enomoto H and Nakamura H designed the research; Enomoto H, Komatsu-Kanatani N, Liu Y, Yoshida K, Okuda Y, Yamamoto T, and Liu W performed the research; Enomoto H, Nakamura H, and Nishiguchi S analyzed the data; Enomoto H and Nakamura H wrote the manuscript.
Correspondence to: Hideji Nakamura, MD, PhD, Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan. nakamura@hyo-med.ac.jp
Telephone: +81-798-456472 Fax: +81-798-456474
Received: June 16, 2009 Revised: September 10, 2009 Accepted: September 17, 2009 Published online: October 31, 2009
Abstract
AIM: To investigate the role of hepatoma-derived growth factor (HDGF) in liver development, especially in the hepatocyte differentiation.
METHODS: We generated transgenic mice which overexpressed HDGF in hepatocytes under the transcriptional control of mouse albumin promoter/enhancer. To examine the effects of HDGF overexpression on hepatocyte differentiation, we investigated the expression patterns of the differentiation marker genes.
RESULTS: The HDGF transgenic mice developed normally and showed no apparent abnormality in the liver. However, the gene expression patterns of the liver in adult transgenic mice were similar to those of the neonatal liver in control mice.
CONCLUSION: These findings suggest that HDGF-overexpression partially suppresses hepatocyte maturation.
