Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications

doi:10.4252/wjsc.v17.i6.108197

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Jun 26, 2025 (publication date) through Jun 25, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Stem Cells. Jun 26, 2025; 17(6): 108197
Published online Jun 26, 2025. doi: 10.4252/wjsc.v17.i6.108197

Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications

Tong-Ming Liu

Tong-Ming Liu, Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, Singapore 138648, Singapore

Author contributions: Liu TM contributed to conceptualization, manuscript writing, and revision; The author read and agreed to the published version of the manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Tong-Ming Liu, PhD, Senior Scientist, Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, No. 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. dbsliutm@yahoo.com

Received: April 8, 2025
Revised: April 25, 2025
Accepted: June 6, 2025
Published online: June 26, 2025
Processing time: 79 Days and 3.5 Hours

Core Tip

Core Tip: Mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) are cell-free nanoparticles that offer several advantages over MSCs, including greater stability and lower immunogenicity. These vesicles have shown significant potential in the treatment of various diseases. This article explored the applications of MSC-EVs in hair regeneration, immunomodulation, and the treatment of acute kidney injury. It also highlighted the challenges associated with MSC-EV-based therapies, underscoring the need for continued research and innovation to address these obstacles and advance MSC-EV development and clinical translation.