High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma

Table 1 Clinical and histopathologic data of the patients and expression of high mobility group-box 3 in correlation with clinicopathologic variables: High mobility group-box 3 overexpression predicts the clinical course (n = 92) (%)

Variables	Samples	HMGB3 overexpression	P value
Age at surgery (yr)
≤ 60	34 (36.96)	20 (60.00)	0.247
> 60	58 (63.04)	30 (51.16)
Gender
Male	61 (66.30)	30 (50.00)	0.649
Female	31 (33.70)	20 (62.5)
Extent of wall penetration
pT1-2	22 (23.91)	6 (26.67)	0.005
pT3-4	70 (76.01)	44 (63.46)
Lymph node metastasis
N0	27 (29.3)	5 (14.29)	0.004
N1-3	65 (70.65)	45 (70.59)
Tumor stage
StageI+ II	37 (40.22)	9 (23.21)	0.001
Stage III + IV	55 (59.78)	41 (56.76)
Tumor localisation
Fundus gastricus and cardia	11 (11.96)	6 (54.55)	0.955
Gastric body	33 (35.87)	21 (63.64)
Gastric antrum	48 (52.17)	23 (47.91)
Histologic grade
G1 + 2	22 (23.91)	9 (40.91)	0.073
G3 + 4	70 (76.09)	41 (58.57)

HMGB3: High mobility group-box 3.

Table 2 Relationship between high mobility group-box 3 overexpression, clinicopathological characteristics and average survival in gastric adenocarcinoma patients (mean ± SD)

Clinicopathological characteristics	Samples (n)	Average survival (mo)	95%CI	P value
Sex
Male	61	41.563 ± 2.823	36.031-47.096	0.308
Female	31	37.24 ± 4.027	29.347-45.133
Age (yr)
≤ 60	34	47.409 ± 4.113	39.348-55.470	0.040
> 60	58	35.143 ± 3.797	27.700-42.585
Histologic grade
G1 + G2	22	40.938 ± 5.238	30.670-51.205	0.323
G3 + G4	70	37.366 ± 3.366	30.769-43.963
Lymph node status
pN0	27	54.800 ± 1.885	51.085-58.515	0.005
pN1-3	65	33.158 ± 3.646	26.012-40.304
Extent of wall penetration
pT1 + 2	22	48.385 ± 3.949	40.645-56.124
pT3 + 4	70	33.447 ± 3.447	26.692-40.203	0.008
TNM stage
StageI+ II	37	47.511 ± 2.927	41.774-53.248	0.007
Stage III + IV	55	32.949 ± 3.266	26.547-39.352
HMGB3 expression
No or low expression	42	49.074 ± 3.648	41.925-57.311	0.006
Overexpression	50	31.00 ± 3.773	23.605-38.395
Location
Stomach fundus	11	31.455 ± 7.193	17.356-45.553	0.2261
Gastric body	33	41.395 ± 3.640	34.226-48.493	0.2972
Gastric antrum	48	41.410 ± 3.211	35.116-47.703	0.9223

¹P = 0.226 vs gastric antrum;

²P = 0.297 vs stomach fundus;

³P = 0.922 vs gastric body. HMGB3: High mobility group box 3.