miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway
Chen Sun, Fu-Jing Wang, Hao-Gang Zhang, Xun-Zheng Xu, Lei Yao, Peng-Fei Qiao, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Rui-Chun Jia, Department of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Author contributions: Jia RC, Yao L and Qiao PF should be considered co-corresponding authors; Qiao PF designed the research and analyzed the data; Jia RC and Yao L performed the research; Zhang HG and Xu XZ contributed new reagents or analytic tools; Wang FJ, Yao L and Qiao PF wrote the article.
Supported by Science Foundation of Education Department of Heilongjiang Province, China, No. 12541430.
Institutional review board statement: This study was approved by the Institutional Review Board of Harbin Medical University, and the protocols used in the study were approved by the Committee of Human Subjects Protection of the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this study.
Data sharing statement: Technical appendices, statistical codes and datasets are available from the corresponding author at email@example.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Peng-Fei Qiao, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. firstname.lastname@example.org
Telephone: +86-13895761713 Fax: +86-451-86297283
Received: September 29, 2016
Peer-review started: October 1, 2016
First decision: December 1, 2016
Revised: December 21, 2016
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: March 14, 2017