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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2017; 23(24): 4422-4427
Published online Jun 28, 2017. doi: 10.3748/wjg.v23.i24.4422
Published online Jun 28, 2017. doi: 10.3748/wjg.v23.i24.4422
Procalcitionin as a diagnostic marker to distinguish upper and lower gastrointestinal perforation
Yang Gao, Xing Zhang, Rui Huang, Jing-Dong Qu, Si-Cong Wang, Rui-Jin Liu, Hong-Liang Wang, Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Kai-Jiang Yu, Hai-Tao Liu, Yan-Song Liu, Department of Critical Care Medicine, the Cancer Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Kai-Jiang Yu, Institute of Critical Care Medicine in Sino Russian Medical Research Center of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Kai Kang, Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Gao Y and Yu KJ contributed equally to this work; Gao Y, Yu KJ, Kang K and Wang HL carried out the studies, participated in data collection, and drafted the manuscript; Liu HT, Zhang X, Huang R, Qu JD, Wang SC, Liu RJ and Liu YS performed the statistical analyses and participated in study design; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81571871 .
Institutional review board statement: The study was approved by the Ethics Committee of Harbin Medical University.
Informed consent statement: All clinical data were collected with informed consent obtained from study participants.
Conflict-of-interest statement: All authors declare that they have no any conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong-Liang Wang, MD, Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin 150086, Heilongjiang Province, China. icuwanghongliang@163.com
Telephone: +86-21-57643271 Fax: +86-21-57643271
Received: March 1, 2017
Peer-review started: March 2, 2017
First decision: April 10, 2017
Revised: April 19, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: June 28, 2017
Peer-review started: March 2, 2017
First decision: April 10, 2017
Revised: April 19, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: June 28, 2017
Core Tip
Core tip: Procalcitionin (PCT) is a rapid, reliable and accurate predictive marker and contributes to assisting the clinicians in identifying upper or lower gastrointestinal perforation (GIP) before laparotomy, and it can be used as a useful supplementary tool for early clinical judgment of perforation site. The results showed that patients with lower GIP exhibited significantly higher APACHE II score, SOFA score and serum PCT level than patients with upper GIP, which might be related to the differences in bacterial load and the severity of sepsis between upper and lower GIP.