Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3797
Peer-review started: February 20, 2017
First decision: March 16, 2017
Revised: March 22, 2017
Accepted: May 4, 2017
Article in press: May 4, 2017
Published online: June 7, 2017
Core tip: Spontaneous tumor regression of hepatocellular carcinoma (HCC) have been reported in several reports although rare. The analyses of the mechanisms underlying this phenomenon is the potential target for the novel therapeutic methods for HCC. For this purpose, we have carefully reviewed 24 cases of spontaneously regressed HCC including cases published in recent 5-years and our case. The minute clinical information and clinical courses are reviewed and summarized. Based on the information, hypoxia and/or systemic inflammation are involved in all cases for which the information regarding the proposed mechanism is available. An accumulation of additional cases and the analysis of mechanism underlying the spontaneous regression of HCC could lead to the development of new therapeutic strategy for HCC.