Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2017; 23(10): 1771-1779
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1771
Catheterization of the gallbladder: A novel mouse model of severe acute cholangitis
Jian-Hua Yu, Hai-Jun Tang, Wei-Guang Zhang, Zhi-Yang Zhu, Xin-Xian Ruan, Bao-Chun Lu
Jian-Hua Yu, Hai-Jun Tang, Zhi-Yang Zhu, Xin-Xian Ruan, Bao-Chun Lu, Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Wei-Guang Zhang, Department of Molecular Medicine and Clinical Laboratory, Shaoxing Second Hospital, Shaoxing 312000, Zhejiang Province, China
Author contributions: Yu JH and Lu BC designed this study; Yu JH and Zhu ZY performed experiments of molecular biology; Zhang WG performed data analysis for this study; Tang HJ and Ruan XX performed animal study; Yu JH and Lu BC wrote this manuscript.
Supported by Zhejiang Provincial Natural Science Foundation of China under grant No. LY17H030001 and No. LQ14H160001; Zhejiang Provincial Public Welfare Technology Application Research Projects under grant No. 2015C33293, No. 2013C33214 and No. 2011C33023; and Research Foundation of Health Bureau of Zhejiang Province under grant No. 2014RCA031 and No. 2016KYB300.
Institutional review board statement: All blood samples from the patients were taken after informed consent and ethical permission was obtained for participation in the study. The institutional review board statement has been provided.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Zhejiang University.
Conflict-of-interest statement: The authors declare that there are no other conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Bao-Chun Lu, Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, 568 North Zhongxing Road, Shaoxing 312000, Zhejiang Province, China.
Telephone: +86-575-88229383
Received: November 22, 2016
Peer-review started: November 23, 2016
First decision: February 19, 2016
Revised: January 22, 2017
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: March 14, 2017
Core Tip

Core tip: Severe acute cholangitis (SAC) is a severe biliary tract infection. Although mice are the most common experimental animal and have a similar anatomical construction of bile ducts to humans, there is still no valid study on establishing a SAC model in mice. To study SAC more easily and exactly, we established a repeatable and reversible mouse model of SAC through cholecystic catheterization under the condition of bile duct ligation.