Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11673
Peer-review started: April 30, 2015
First decision: June 2, 2015
Revised: July 11, 2015
Accepted: September 15, 2015
Article in press: September 15, 2015
Published online: November 7, 2015
Core tip: The mortality rate of gastric cancer is as high as 70% worldwide due to the rapid and uninhibited metastasis and invasiveness of the disease. Although the relationship between the mitogen-activated protein kinase (MAPK) signaling pathway and cancer metastasis and invasion has been widely researched, few studies have focused on gastric cancer. Here we review the function of the three central kinases of the MAPK signaling pathway, ERK, JNK and p38, in the metastasis and invasion of gastric cancer, and we attempt to provide support for further in-depth study and clinical application.