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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2015; 21(11): 3441-3446
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3441
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3441
Icotinib plus gemcitabine for metastatic pancreatic cancer: A case report
Jing Zhao, Hong Shen, Han-Guang Hu, Jian-Jin Huang, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Zhao J and Shen H wrote the manuscript; Hu HG participated in the clinical management of the patient; Huang JJ was in charge of the patient; and all authors approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81201640; Department of Education of Zhejiang Province of China, No. Y201225802; and Medical and Technology Plan of Zhejiang Province of China, No. 2013KYA093.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Jin Huang, MD, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jie-Fang Road, Hangzhou 310009, Zhejiang Province, China. hhjj@medmail.com.cn
Telephone: +86-571-87784795 Fax: +86-571-87767088
Received: August 8, 2014
Peer-review started: August 9, 2014
First decision: September 15, 2014
Revised: October 5, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: March 21, 2015
Peer-review started: August 9, 2014
First decision: September 15, 2014
Revised: October 5, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: March 21, 2015
Core Tip
Core tip: Patients with advanced metastatic pancreatic cancer have a poor prognosis. Currently, treatments available in China are accompanied by high toxicity and cost, with minimal benefit. Icotinib is a newly developed oral epidermal growth factor receptor tyrosine kinase inhibitor, which was combined with standard gemcitabine therapy for treatment of metastatic pancreatic cancer in a 64-year-old male patient. This case report demonstrates that the novel regimen produced partial remission with marked shrinkage of the pancreatic mass. Thus, icotinib combined with gemcitabine may be a promising therapeutic alternative for metastatic pancreatic cancer.