Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3441
Peer-review started: August 9, 2014
First decision: September 15, 2014
Revised: October 5, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: March 21, 2015
Core tip: Patients with advanced metastatic pancreatic cancer have a poor prognosis. Currently, treatments available in China are accompanied by high toxicity and cost, with minimal benefit. Icotinib is a newly developed oral epidermal growth factor receptor tyrosine kinase inhibitor, which was combined with standard gemcitabine therapy for treatment of metastatic pancreatic cancer in a 64-year-old male patient. This case report demonstrates that the novel regimen produced partial remission with marked shrinkage of the pancreatic mass. Thus, icotinib combined with gemcitabine may be a promising therapeutic alternative for metastatic pancreatic cancer.