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World J Gastroenterol. Jan 28, 2014; 20(4): 1061-1066
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1061
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1061
Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates
Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea
Author contributions: Yoon SB and Park JM designed the study; Yoon SB and Park JM analyzed the results; Yoon SB, Park JM, Lee JY, Baeg MK, Lim CH, Kim JS, Cho YK, Lee IS, Kim SW and Choi MG collected the clinical data, wrote and edited the paper, and approved the final version.
Correspondence to: Jae Myung Park, MD, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-856, South Korea. parkjerry@catholic.ac.kr
Telephone: +82-2-22586023 Fax: +82-2-22582055
Received: August 12, 2013
Revised: September 20, 2013
Accepted: December 13, 2013
Published online: January 28, 2014
Revised: September 20, 2013
Accepted: December 13, 2013
Published online: January 28, 2014
Core Tip
Core tip: Proton pump inhibitors (PPIs) are widely used for long periods. It is important to know whether long-term PPI pretreatment can influence Helicobacter pylori (H. pylori) eradication rates. There have been debates about the effect of PPI pretreatment on H. pylori eradication rate, although most previous studies have focused on the relatively short-term use of PPI. Our study investigated the impact of PPI pretreatment on H. pylori eradication rates based on different periods of treatment, including long-term pretreatment. Our data showed that PPI pretreatment did not affect H. pylori eradication rates, regardless of the medication period.