Liu YQ, Zhao H, Ning T, Ke Y, Li JY. Expression of 1A6 gene and its correlation with intestinal gastric carcinoma. World J Gastroenterol 2003; 9(2): 238-241 [PMID: 12532438 DOI: 10.3748/wjg.v9.i2.238]
Corresponding Author of This Article
Prof. Ji-You Li, Department of Pathology, Peking University school of Oncology, Beijing 100036, China. lijiyou@263.net and Prof. Yang Ke, Laboratory of Genetics, Peking University school of Oncology, Beijing 100034, China. keyang@mx.cei.gov.cn
Article-Type of This Article
Gastric Cancer
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World J Gastroenterol. Feb 15, 2003; 9(2): 238-241 Published online Feb 15, 2003. doi: 10.3748/wjg.v9.i2.238
Expression of 1A6 gene and its correlation with intestinal gastric carcinoma
Yi-Qiang Liu, Hong Zhao, Tao Ning, Yang Ke, Ji-You Li
Yi-Qiang Liu, Ji-You Li, Department of Pathology, Peking University school of Oncology, Beijing 100036, China
Hong Zhao, Tao Ning, Yang Ke, Laboratory of Genetics, Peking University school of Oncology, Beijing 100034, China
Author contributions: All authors contributed equally to the work.
Supported by National Key Fundamental Research 973 Project, No1998051203 and National High Technology Research and Development Program of China (863 Program), No2001AA221121
Correspondence to: Prof. Ji-You Li, Department of Pathology, Peking University school of Oncology, Beijing 100036, China. lijiyou@263.net and Prof. Yang Ke, Laboratory of Genetics, Peking University school of Oncology, Beijing 100034, China. keyang@mx.cei.gov.cn
Telephone: +86-10-88121122 Ext 2331
Received: August 13, 2002 Revised: August 25, 2002 Accepted: September 5, 2002 Published online: February 15, 2003
Abstract
AIM: To investigate the expression of 1A6 gene in the lesions during the development of intestinal gastric carcinoma.
METHODS: One hundred and thirty-six cases of intestinal metaplasia (IM) from surgical resections and biopsy were classified by mucous staining. Expression of 1A6 in all cases was detected using immunohistochemical S-P method.
RESULTS: The positive rates of 1A6 in normal and superficial gastritis (SG), severe atrophic gastritis (SAG), type I, II, III IM, dysplasia (Dys) and intestinal gastric carcinoma (IGC) were 12.2%, 16.7%, 7.1%, 22.6%, 47.8%, 46.9% and 60.8%, respectively. A significant difference among type III IM and SG, SAG, type I and II IM was found (P < 0.01), the difference between type III and Dys, IGC being not significant.
CONCLUSION: As a new tumor-related gene, expression of 1A6 may be an effective parameter to predict the malignant transformation of precancerous lesion to gastric carcinoma.
