Du YP, Deng CS, Lu DY, Huang MF, Guo SF, Hou W. Relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans. World J Gastroenterol 2000; 6(1): 107-110 [PMID: 11819534 DOI: 10.3748/wjg.v6.i1.107]
Corresponding Author of This Article
Dr. Yi-Ping Du, Department of Digestive Medi cine, Shenzhen Central Hospital, Lian Hua Bei, Futian District, Shenzhen 518036, Guangdong Province, China. Szzxyy@nenpub.szptt.net.cn
Article-Type of This Article
Original Articles
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Yi-Ping Du, Chang-Sheng Deng, Mei-Fang Huang, Department of Gastroenterology, the Second Affiliated Hospital, Hubei Medical University, Wuhan 430071, Hubei Province, China
De-Yin Lu, Shu-Fang Guo, Wei Hou, Department of Clinical Cancer, Institute of Virus Research of Basic Medicine, Hubei Medical University, Wuhan 430071, Hubei Province, China
Yi-Ping Du, female, born on 1964-01-03 in Wuhan, Hubei Province, graduated from Hubei Medical University as a doctor in 1998, majoring peptic ulcer immunology-genetics, now working in Shenzhen Central Hospital.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Yi-Ping Du, Department of Digestive Medi cine, Shenzhen Central Hospital, Lian Hua Bei, Futian District, Shenzhen 518036, Guangdong Province, China. Szzxyy@nenpub.szptt.net.cn
Received: July 21, 1999 Revised: September 22, 1999 Accepted: October 12, 1999 Published online: February 15, 2000
Abstract
AIM: To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans. METHODS: Seventy patients with duodenal ulcer and fifty health y controls were examined for HLA-DQA1 genotypes. HLA-DQA1 typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific restriction enzymes (PCR-RFLP), i.e. Apal I, Bsaj I, Hph I, Fok I, Mbo II and Mnl I.
RESULTS: The allele frequencies of DQA1*0301 and DQA1*0102 in patients with duodenal ulcer were significantly higher and lower respectivel y than those in healthy controls (0.40 vs 0.20, P = 0.003, Pc orret = 0.024) and (0.05 vs 0.14, P = 0.012, but P corret > 0.05), respectively.
CONCLUSION: DQA1*0301 is a susceptible gene for duodenal ulcer in Wuhan Hans, and there are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients and healthy controls.
