Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.38
Revised: November 27, 1998
Accepted: December 16, 1998
Published online: February 15, 1999
AIM To assess the possible roles of cytokines (TNF-α, IFN-γ, IL-6 and IL-8) in liver damage of hepatitis B.
METHODS The serum TNF-α, IFN-γ, IL-6 and IL-8 were detected by ELISA in 66 patients with hepatitis B and 20 healthy blood donors.
RESULTS TNF-α and IL-6 in all types of clinical hepatitis B were significantly higher than those in healthy blood donors (P < 0.05 ); meanwhile the levels of TNF-α, IFN-γ, IL-6 and IL-8 in the patients with fulminant hepatitis B were much higher than those in the patients with acute hepatitis B(P < 0.05); the level of TNF-α was positively correlated with the levels of IFN-γ, Il-6 and IL-8 in all types of hepatitis B (rIFN = 0.24, rIL-6 = 0.35, rIL-8 = 0.44) and the TNF-α, IFN-γ, IL-6 and IL-8 were positively correlated with serum bilirubin (P < 0.05). Dynamic changes of these cytokines were observed in the course of acute and fulminant hepatitis. The level of IFN-γ peaked in the initial period of acute hepatitis and early stage of hepatic coma in fulminant hepatitis; TNFα, IL-6 and IL-8 increased with exacer-bation, and reached a peak when the liver da-mage was most serious, then decreased when patient conditions were improved.
CONCLUSION The increased cytokines were re-lated to the inflamm ation of liver cells and multi-ple factors may play certain roles in liver dam-age.