Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.222
Revised: April 2, 1998
Accepted: May 16, 1998
Published online: June 15, 1998
AIM: To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.
METHODS: Gastric acid was continuously washed with 37 °C saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv) by a syringe pump and their effect on pentagastrin-induced (10 μg·kg·h, iv) gastric acid secretion was observed.
RESULTS: The inhibitory effect of HA (1 μg, icv) on gastric acid secretion was blocked by subdiaphragmatic vagotomy, and pretreatment with atropine (0.005 mg·kg·h, iv). Pretreatment with somatostatin antagonist, cyclo-[7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)], (2 μg-4 μg·kg·100 min, iv) could also block the inhibitory effect of HA on gastric acid secretion in a dose dependent manner.
CONCLUSION: The inhibitory effect of centrally administrated HA on gastric acid secretion may be mediated by vagi, acetylcholine M receptor and somatostatin.