©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 16167-16177
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16167
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16167
Table 2 Sum-up of signal pathways in hepatocellular carcinoma
| Signaling pathways | Cell survival | Cell proliferation | Cell differentiation | Cell migration | Angiogenesis | |
| Receptor tyrosine kinase signaling pathways | HGF/c-MET | √ | √ | √ | √ | |
| EGF(TGF-α)/EGFR | √ | √ | ||||
| IGF/IGFR | √ | √ | √ | |||
| VEGF/VEGFR | √ | |||||
| PDGF/PDGFR | √ | |||||
| TGF-β1/SMAD | √ | √ | ||||
| Intercellular kinase signaling pathways | RAF/MEK/ERK | √ | √ | √ | √ | |
| PI3K/AKT/mTOR | √ | √ | √ | |||
| Wnt/β-catenin | √ | √ | √ | √ | ||
| Hedgehog | √ | √ | √ | |||
| NK-κB, JAK/STAT3 | √ | √ | √ | √ | √ | |
- Citation: Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors. World J Gastroenterol 2014; 20(43): 16167-16177
- URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16167.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16167