Effect of liver regeneration on malignant hepatic tumors

doi:10.3748/wjg.v20.i43.16167

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2014; 20(43): 16167-16177
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16167

Effect of liver regeneration on malignant hepatic tumors

Ji-Hua Shi, Pål-Dag Line

Ji-Hua Shi, Pål-Dag Line, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway

Author contributions: Shi JH and Line PD contributed equally to this work; Shi JH and Line PD designed the review and performed the literature review; Shi JH wrote the manuscript; Line PD provided substantive revisions; all authors approved the final version of the manuscript.

Correspondence to: Pål-Dag Line, MD, PhD, FEBS (Tx), Chairman, Department of Transplantation Medicine, Institute for Surgical Research, Oslo University Hospital, Postboks 4950, Nydalen 0424, Oslo, Norway. p.d.line@medisin.uio.no

Telephone: +47-23-070509 Fax: +47-23-070510

Received: March 3, 2014
Revised: May 5, 2014
Accepted: June 21, 2014
Published online: November 21, 2014

Core Tip

Core tip: The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue, and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.