Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing

Figure 3 Quasispecies composition of the hepatitis B virus core region in the 3 sequentially analyzed samples. A: Baseline variants (1-15) in percentages ≥ 1%; B: Treatment-free variability; C: Lamivudine sample variability of the most frequent amino acid substitutions defined in Figure 2. Linkage analysis was also performed attending these most variable codons.