Fatigue prevalence in men treated for prostate cancer: A systematic review and meta-analysis

Table 1 Characteristics of included studies

Ref.	Country	Time of case inclusion	Study design	Sample size	Number of CRF cases	The incidence of CRF, %	Scale	Assessment time	Treatment
Yu and Chen[21]	China	2015.4-2017.9	Cross-sectional	174	109	62.64	BFI	NA	ADT
Wang et al[22], 2017	China	2006.12-2016.12	Longitudinal	147	89	60.54	BFI	NA	NA
Ashton et al[11], 2019	United Kingdom	2016.10-2017.3	Cross-sectional	62	15	24.19	BFI	T1	RARP/ADT
Baden et al[28], 2020	Ireland	1995.1-2011.3	Cross-sectional	2879	556	19.31	EORTC QLQ-C30	NA	NA
Feng et al[23], 2017	United States	2009.9-2013.11	Longitudinal	34	14	41.17	FACT-F	T2	EBRT
Feng et al[8], 2019	United States	2009.9-2015.2	Longitudinal	47	16	34.04	FACT-F	T2	EBRT
Gonzalez et al[10], 2018	Spain	2014.7-2014.9	Longitudinal	26	5	19.23	FACT-F	T1	EBRT
Feng et al[7], 2020	United States	2009.9-2015.11	Longitudinal	64	36	56.25	FACT-F	T1/T2	ADT + RT/EBRT
Maliski et al[24], 2005	United States	NA	Longitudinal	147	28	19.04	SF-36	NA	NA
Nelson et al[12], 2016	United States	2008.9-2013.10	Case control study	145	35	24.13	BFI	T1/T2	ADT/RP
Saligan et al[25], 2016	United States	2009.4-2013.12	Longitudinal	47	39	82.97	FACT-F	T1	EBRT
Storey et al[13], 2012	United Kingdom	2005.8-2005.11	Cross-sectional	377	216	57.29	BFI	T2	RT/ RP
Jones et al[27], 2016	Canada	NA	Longitudinal	529	90	17.01	FACT-F	NA	NA
Ozdemir et al[26], 2019	Turkey	2014.3-2018.9	Cross-sectional	58	31	53.44	FACT-F	T1	NA

ADT: Androgen deprivation therapy; BFI: Brief Fatigue Inventory; CRF: Cancer-related fatigue; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Version 3.0; EBRT: External beam radiation therapy; FACT-F: 13-Item Functional Assessment of Cancer Therapy- Fatigue; NA: Not reported; RARP: Robotic-assisted radical prostatectomy; RP: Radical prostatectomy; RT: Radiation therapy; SF-36: 36-Item health survey; T1: During the period of treatment; T2: ≥ 1 year after treatment.