Zhang HG, Jiang YT, Dai SD, Li L, Hu XN, Liu RZ. Application of intelligent algorithms in Down syndrome screening during second trimester pregnancy. World J Clin Cases 2021; 9(18): 4573-4584 [PMID: 34222424 DOI: 10.12998/wjcc.v9.i18.4573]
Corresponding Author of This Article
Rui-Zhi Liu, MD, Professor, Center for Reproductive Medicine and Center for Prenatal Diagnosis, First Hospital, Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun 130021, Jilin Province, China. lrz410@126.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 2 Some data samples used for feature selection
ID
Expected age at delivery
AFP concentration
hCGb concentration
uE3 concentration
Body weight
Gestational age
Result
783
19.633
23.22
30.71
5.35
60.7
17.6
1
1504
39.403
44.1
30.41
3.87
62
16.4
1
4338
30.527
23.73
26.29
5.86
65
18.5
1
6050
34.489
11.53
52.42
9.8
52.5
20.6
1
6412
41.966
24.51
49.67
3.91
58
19
1
Table 3 Experimental results
Algorithm
DR
FPR
Time
CART+AdaBoost
0.2941
0.2857
0:09:54
SVM+SMOTE-Tomek
1
0.0183
0:09:01
CART+AdaBoost+SMOTE-Tomek,maxdepth=2,iter=100
0.9777
0.2337
0:02:14
CART+AdaBoost+SMOTE-Tomek,maxdepth=2,iter=500
0.9909
0.1382
07:18.0
CART+AdaBoost+SMOTE-Tomek,maxdepth=5,iter=100
0.9987
0.0102
0:03:15
CART+AdaBoost+SMOTE-Tomek,maxdepth=5,iter=500
0.9993
0.0028
0:11:37
SVM+EasyEnsemble
1
0.9973
0.00348
SVM+ADASYN
0.9863
0.0932
0:11:05
Table 4 Comparison of algorithms when different T21 threshold values were selected
Risk-cutoff value
Age
SVM
Statistical methods
FPR
DR
FPR
DR
270
Overall
0.009369
0.9295
0.032
0.913
50
Overall
0.003081
0.913
0.007
0.82
150
Overall
0.007039
0.9268
0.019
0.885
250
Overall
0.008197
0.9178
0.03
0.91
500
Overall
0.01775
0.9266
0.053
0.937
750
Overall
0.02299
0.9319
0.072
0.95
1000
Overall
0.03321
0.9305
0.088
0.958
Citation: Zhang HG, Jiang YT, Dai SD, Li L, Hu XN, Liu RZ. Application of intelligent algorithms in Down syndrome screening during second trimester pregnancy. World J Clin Cases 2021; 9(18): 4573-4584