Long-term survival of two patients with recurrent pancreatic acinar cell carcinoma treated with radiofrequency ablation: A case report

Table 1 Overview of case reports and case series with metastases of pancreatic acinar cell carcinoma treated with radiofrequency ablation

Report	Metastatic at diagnosis	First-line therapy	Relapse	Second-line therapy	Overall survival
Béchade et al[25], 2016	Two liver metastases	GEMOX 6 cycles + radiation therapy for the primary lesion + radiofrequency treatment for the two liver metastases	-	-	Disease-free at 6 mo after radiotherapy and RFA
Cananzi et al[24], 2013	Multiple liver metastases	1 Docetaxel, irinotecan and cetuximab 2 February 2002: Distal pancreatosplenectomy with right hepatectomy; adjuvant chemotherapy with docetaxel, irinotecan and cetuximab	Liver 5 mo	1 July 2002: Gemcitabine, oxaliplatin and cetuximab and then continued only cetuximab (toxicity) 2 May 2006: Resection of the liver and peritoneal metastases, extensive lymphadenectomy, followed by oxaliplatin (hypersensitivity reaction) and later carboplatin, gemcitabine, cetuximab and bevacizumab 3 October 2007 and January 2008: 2 RFAs (17 and 20 mo after the second surgery) for hepatic metastases, followed by carboplatin (later stopped), gemcitabine, cetuximab and bevacizumab (later stopped); PD at 35 mo after the second surgery 4 April 2009: Repeat para-aortic lymphadenectomy, intraoperative hepatic RFA, followed by gemcitabine, capecitabine, and cetuximab 5 April 2010: Right/left partial adrenalectomy, partial peritonectomy, extensive lymphadenectomy, followed by liposomal doxorubicin 6 August 2010: Nab-paclitaxel with panitumumab 7 March 2012: Resection of a retroperitoneal mass and completion of left adrenalectomy 8 June 2012: Left frontal brain metastasis resection 9 August 2012: Nab-paclitaxel and panitumumab	Over 11 years after diagnosis and over 10 years after the first surgery
Armstrong et al[23], 2011	One liver metastasis	October 2003: Distal pancreatectomy and splenectomy + RFA on liver metastasis. Adjuvant therapy: 3 cycles of gemcitabine and cisplatin followed by radiation to the pancreatic bed concomitant with five weekly cycles of cisplatin	Liver 6 mo	1 April 2004: Hepatic RFA + 5 cycles of weekly paclitaxel with thalidomide; continued only paclitaxel (toxicity) 2 February 2005: Capecitabine 3 August 2005: Imatinib 4 October 2005: Etoposide 5 December 2005: Liposomal doxorubicin 6 February 2007: Hepatic intra-arterial brachytherapy with SIR-spheres 7 January 2008: RFA for 1 liver lesion retreated with cryotherapy 8 May 2008: stereotactic radiosurgery of a pericardial lymph node 9 July 2008: sorafenib and temozolomide 10 November 2008: external beam radiation of a progressive liver lesion 11 January 2009: nab-paclitaxel and bevacizumab, stopped for toxicity	DOD at 68 mo
Butturini et al[16], 2011	No	Whipple (T3N0MX stage II R0)	Multiple liver metastases 28 mo	1 Gemcitabine, capecitabine and oxaliplatin 2 RFA + chemoembolization	DOD at 45 mo

DOD: Dead of disease; RFA: Radiofrequency ablation; GEMOX: Gemcitabine, oxaliplatin; PD: Progressive disease.