Basic Study
Copyright ©The Author(s) 2019.
World J Clin Cases. Jul 6, 2019; 7(13): 1582-1590
Published online Jul 6, 2019. doi: 10.12998/wjcc.v7.i13.1582
Table 1 Demographic and clinical characteristics of study participants
TinnitusControlP-value
Age (yr)44-72 (51.8 ± 10.6)44-71(51.7 ± 9.3)0.8611
Gender (M/F)6/56/51.0002
Education (yr)3-12 (7.1 ± 2.6)4-14 (8.6 ± 2.9)0.3412
Tinnitus duration (yr)5.91 ± 6.46NANA
Average threshold (dB HL)37.16 ± 24.39NANA
Tinnitus severity
THI score36-80 (57.8 ± 20.6)NANA
VAS score0-4 (1.4 ± 1.9)NANA
Tinnitus laterality
Left3NANA
Right4NANA
Both3NANA
Center of head1NANA
Table 2 Regional brain area in tinnitus patients compared with control subjects
Brain region (AAL)MNI coordinates of the peak voxel(mm)
Voxel size (mm3)Peak T value
XYZ
Right inferior temporal gyrus49.5-12-31.52742.75
Right parahippocampa gyrus19.5-3-247145.87
Right rectal gyrus634.5-22.56844.19
Left middle frontal gyrus-19.536-16.52040.31
Left rectus gyrus-916.5-152236.64
Left frontal Med Orb-7.543.5-10.51338.57
Right hippocampus24-31.502340.41
Right inferior frontal gyrus43.52431436.51
Left middle frontal gyrus-4.548302136.88
Table 3 Significant brain area between idiopathic tinnitus patients at baseline and after therapy
Brain region (AAL)MNI coordinates of the peak voxel(mm)
Voxel size (mm3)Peak T value
XYZ
Increased neural activity
Right parahippocampa gyrus3016.5-36323.88
Right insula42-12-31274.12
Right superior temporal gyrus-45-189153.45
Left inferior parietal lobule-36-43.524243.91
Right Superior frontal gyrus25.5-7.573.5553.87
Left precentral gyrus-39-1866474.63
Left insula-45-189423.45
Decreased neural activity
Left postcentral gyrus61.5-31.540.552-5.84
Left inferior temporal gyrus-61.5-27-2124-3.56