Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2019; 7(13): 1582-1590
Published online Jul 6, 2019. doi: 10.12998/wjcc.v7.i13.1582
Neural metabolic activity in idiopathic tinnitus patients after repetitive transcranial magnetic stimulation
Ying Kan, Wei Wang, Shu-Xin Zhang, Huan Ma, Zhen-Chang Wang, Ji-Gang Yang
Ying Kan, Wei Wang, Shu-Xin Zhang, Huan Ma, Ji-Gang Yang, Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Zhen-Chang Wang, Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Kan Y, Wang ZC, and Yang JG designed the research; Kan Y, Wang W, and Zhang SX performed the research; Kan Y and Ma H analyzed the data; Kan Y wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81771860.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Beijing Friendship Hospital, Capital Medical University and adhered to the tenets of the Declaration of Helsinki.
Conflict-of-interest statement: None.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at [cjr.wzhch@vip.163.com]. Participants gave informed consent for data sharing. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhen-Chang Wang, MD, Chief Doctor, Professor, Department of Radiology, Capital Medical University, Beijing Friendship Hospital, No. 95, Yongan Road, Xicheng District, Beijing 100050, China. cjr.wzhch@vip.163.com
Telephone: +86-10-63138625 Fax: +86-10-63138625
Received: March 6, 2019
Peer-review started: March 8, 2019
First decision: April 18, 2019
Revised: April 21, 2019
Accepted: May 2, 2019
Article in press: May 2, 2019
Published online: July 6, 2019
Core Tip

Core tip: In this study, we focused on changes of neural metabolic activity in idiopathic tinnitus (IT) patients after repetitive transcranial magnetic stimulation (rTMS) treatment and further investigated changes in cortical activities of the whole brain. We found that after rTMS treatment, IT patients had increased activities in auditory, non-auditory, and limbic systems, and the activity decreased only in the target area with no statistically significant symptom alleviation. Our study may provide a new direction for rTMS target area.