Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice

Figure 4 Morphological changes in liver sections obtained from transgenic mice infected with hepatitis B virus. Mice were sacrificed, and the livers were harvested and prepared for observation on the 7^th d after treatment. A: Blank control group; B: Unrelated sequence control group; C: Lamivudine control group; D: Anti-sense-LNA treatment control group; E: Anti-gene-LNA treatment group. Liver sections were stained with hematoxylin and eosin (original magnification, × 200). There were no significant morphological changes in the liver among groups. LNA: Locked nucleic acid.