Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice
Shu-Rong Xiao, Gui-Dan Xu, Wu-Jun Wei, Bin Peng, Yi-Bin Deng, Department of Medical Laboratory Science, the Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Yi-Bin Deng, Department of Hepatobiliary Disease Center, Guangxi Clinic Medicine Research, Baise 533000, Guangxi Zhuang Autonomous Region, China
Author contributions: Xiao SR and Deng YB conceived the study, analyzed the data, drafted the manuscript; Xu GD and Wei WJ helped revise the manuscript critically for important intellectual content; Peng B collect the data; Deng YB helped design the study.
Supported by National Natural Science Foundation of China, No. 81460123; Guangxi Graduate Innovation Program, No. 201601005; and Guangxi Clinic Medicine Research Center of Hepatobiliary Disease, No. AD17129025.
Institutional review board statement: This study was approved by the Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Ethics and Welfare Committee of Affiliated Hospital of Youjiang Medical College for Nationalities.
Conflict-of-interest statement: The authors declare that they have no competing interests.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Bin Deng, PhD, Professor, Department of Medical Laboratory Science, the Affiliated Hospital of Youjiang Medical College for Nationalities, 18 Zhongshan 2nd Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. email@example.com
Telephone: +86-776-2852592 Fax: +86-776-2852592
Received: January 24, 2018
Peer-review started: February 2, 2018
First decision: March 7, 2018
Revised: March 29, 2018
Accepted: June 7, 2018
Article in press: June 8, 2018
Published online: August 16, 2018