Editorial
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2016; 4(8): 195-201
Published online Aug 16, 2016. doi: 10.12998/wjcc.v4.i8.195
Non-pharmacological intervention for posterior cortical atrophy
Agnès Weill-Chounlamountry, Jorge Alves, Pascale Pradat-Diehl
Agnès Weill-Chounlamountry, Pascale Pradat-Diehl, Département de Médecine Physique et de Réadaptation, AP-HP Hôpitaux Pitié-Salpêtrière Charles Foix, F-75013 Paris, France
Agnès Weill-Chounlamountry, GRC-UPMC, Handicap Cognitif et Réadaptation, F-75013 Paris, France
Jorge Alves, Center for Evidence-Based NeuroRehabilitation, CEREBRO - Brain Health Center, 4710-409 Braga, Portugal
Pascale Pradat-Diehl, Laboratoire d’Imagerie Biomédicale (LIB), Inserm U1146, Sorbonne Universités UPMC UMCR2 - CNRS UMR7371, F-75013 Paris, France
Author contributions: Weill-Chounlamountry A conceptualized the work, performed the article search, collected the data and drafted the initial version of the manuscript; Alves J and Pradat-Diehl P contributed to further revisions of the paper; all authors read and approved the final version of the manuscript before submission.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jorge Alves, PhD, Center for Evidence-Based NeuroRehabilitation, CEREBRO - Brain Health Center, Rua Nova de Santa Cruz 317, 4710-409 Braga, Portugal. jorge.alves@cerebro.org.pt
Telephone: +351-253-137687 Fax: +351-253-137687
Received: January 13, 2016
Peer-review started: January 15, 2016
First decision: April 15, 2016
Revised: April 26, 2016
Accepted: May 17, 2016
Article in press: May 27, 2016
Published online: August 16, 2016

Abstract

Posterior cortical atrophy (PCA) is a rare neurodegenerative condition characterized by progressive visual-perceptual deficits. Although the neurocognitive profile of PCA is a growing and relatively well-established field, non-pharmacological care remains understudied and to be widely established in clinical practice. In the present work we review the available literature on non-pharmacological approaches for PCA, such as cognitive rehabilitation including individual cognitive exercises and compensatory techniques to improve autonomy in daily life, and psycho-education aiming to inform people with PCA about the nature of their visual deficits and limits of cognitive rehabilitation. The reviewed studies represented a total of 7 patients. There is a scarcity of the number of studies, and mostly consisting of case studies. Results suggest non-pharmacological intervention to be a potentially beneficial approach for the partial compensation of deficits, improvement of daily functionality and improvement of quality of life. Clinical implications and future directions are also highlighted for the advancement of the field, in order to clarify the possible role of non-pharmacological interventions, and its extent, in PCA.

Key Words: Cognitive rehabilitation, Posterior cortical atrophy, Alzheimer’s disease, Non-pharmacological intervention, Neuropsychological rehabilitation

Core tip: Non-pharmacological interventions remain scarcely explored as therapies for posterior cortical atrophy (PCA). Preliminary evidence suggests the potential of cognitive rehabilitation and psychoeducation. There is a need for randomized controlled trials evaluating the efficacy and cost-effectiveness of non-pharmacological approaches in PCA.


Citation: Weill-Chounlamountry A, Alves J, Pradat-Diehl P. Non-pharmacological intervention for posterior cortical atrophy. World J Clin Cases 2016; 4(8): 195-201
INTRODUCTION

Posterior cortical atrophy (PCA) or Benson’s syndrome[1] is a rare neurodegenerative syndrome mainly characterized by progressive visual-perceptual deficits. The precise prevalence and incidence of PCA are yet to be established, due to an overall lack of knowledge of this syndrome[2,3]. However, Snowden et al[4] reported a 5% prevalence of PCA in a population of Alzheimer’s disease (AD) subjects. PCA is often described as a visual variant of AD in which there are predominant neurovisual impairments[5] with the presence of common AD brain changes such as senile and neurofibrillary plaques[6]. This latter classification is controversial because PCA can also occur as a result of other neurodegenerative diseases such as cortico-basal degeneration, Lewy body dementia or prion disease[7-9]. In those individuals with PCA with underlying Alzheimer pathology, the distribution of plaques and tangles differs from the common amnestic AD variant due to their predominance in posterior cerebral regions, sparing the middle regions of the temporal lobes[10] and also involving the white matter lateralized on the right, along visual pathways[11].

The course of PCA is characterized by insidious and progressive impairment of cognitive functions, primarily consisting of central visual deficits and excluding peripheral visual deficits or acquired focal lesions[5]. PCA patients typically present with a mean age of onset of 60 years and an average diagnostic delay of 4 years[12].

Homonymous lateral hemianopsia is often reported anecdotally in PCA, whereas this sign could be an early indicator in some patients[13]. Praxic and spatial disorders (dressing apraxia, constructional apraxia or ideomotor apraxia) are often associated[5,11,12,14]. Some studies have reported the presence of a significant reduction in verbal fluency as well as an anomia[10,15,16] related to anatomical and functional abnormalities of the left temporal-parietal junction in some patients[10,16] and deficits in working memory[15]. In the early stage of PCA, episodic memory and executive functions are relatively preserved, when comparing to typical/amnestic AD[5,11].

Daily life is severely affected by impairments in visuospatial orientation or visual recognition, and in the beginning of the disease, complaints of subjects with PCA encompass daily functioning. Difficulties in reading are the most frequently reported complaints[3,9,17-25], occurring in 80% of PCA patients[26]. In this regard, reading of text is more impaired than reading of isolated words or letters, with patients losing lines while reading and overlapping words, failing in using a “letter by letter” strategy[26] and sometimes not even being able to read their own writing[17,25]. As it can be inferred, visuospatial impairments might lead to the inability to perform simple activities of daily life [dressing[9,19,20,23,25] (how to orientate clothes to dress)] and instrumental activities such as finding the handle of a car[21], using a telephone[18] or looking at an analogue watch[18,22]. Patients can experience limitations such as be hesitating on how to sit[19], difficulties to find a way in unfamiliar surroundings[9,20,27] or even sometimes in familiar surroundings[25,28]. Gradually, PCA patients lose the ability to draw or write[20,24] and to drive a car[9,11,24,25], which might contribute to losing their job[9,18,28] when patients are of working age.

Despite a relatively well-known neurocognitive profile, non-pharmacological intervention in PCA is still rarely described or implemented, even though it is recommended[29,30] since its benefits are encouraging for the PCA patient’s daily life[25,31-33].

In the available literature, two types of intervention approaches have been reported previously: (1) cognitive rehabilitation programs[25,31,32], aiming at maximizing patient cognition and functionality; and (2) psycho-educative programs[33] that consist of a didactic and therapeutic approach for people with PCA and their caregivers with the aim of facilitating coping, understanding of the disease, and reducing its impact in daily life.

Cognitive rehabilitation aims to address impaired cognitive functions (memory, executive functions, attention, etc.) and can be performed individually or in a group. Cognitive rehabilitation is a therapeutic intervention approach that aims to improve functioning of patients in daily life, whether in limitation of activities or in restriction of participation, as referenced by the International Classification of Functioning, Disability and Health (ICF). Furthermore, cognitive rehabilitation requires identifying individual needs and goals with suitable assessments in order to implement restorative or compensatory interventions.

Cognitive rehabilitation has shown evidence of efficacy in the treatment of cognitive disorders acquired after stroke[34,35]. Indeed, this intervention approach has also shown some evidence of efficacy in people with AD[36-39]. In a pilot study, Clare et al[38] has shown that people with early-stage dementia could benefit from cognitive rehabilitation and these subjects could personally identify individual goals of daily life. The research was carried out as a single-blind, randomized controlled study, in which the three following interventions (during eight sessions) were applied to 69 subjects with dementia at an early stage: (1) cognitive rehabilitation (n = 23); (2) relaxation therapy, as a placebo condition (n = 24); and (3) treatment as usual (mainly pharmacological) (n = 22). Goal performance improved for subjects who received cognitive rehabilitation with maintenance beyond 6 mo. without any intervention. Conversely, no change was noticed for the other two groups.

CURRENT STATE OF ART
Cognitive rehabilitation

Presently, only three case studies on three patients[25,31,32] fall within the scope of cognitive rehabilitation approaches. These described similar comprehensive approaches, which included: (1) improving autonomy in daily life as a goal; (2) individual cognitive training exercises aimed at reducing cognitive deficits; (3) introduction of compensatory techniques; and (4) a psycho-educational aspect aiming to explain to people with PCA the nature of their visual deficits and to inform them about the limits of cognitive rehabilitation as a comprehensive remediation in degenerative diseases. The first case was reported by Roca et al[32] and involved a 64-year-old man with PCA characterized by visual agnosia and with a complete Balint’s syndrome (simultagnosia, optic ataxia and oculomotor disorders). Namely, there was a dorsal simultagnosia responsible for difficulties such as in discerning more than one object at the same time due to an attentional limitation (so that visual recognition was focusing on an isolated part of the object), optic ataxia, as well as oculomotor disorders and reading difficulties. A second case was reported by Weill-Chounlamountry et al[25] and involved a 60-year-old woman who presented with progressive visual disorders since age 54. She presented with visual agnosia, simultagnosia, visual-constructive apraxia, left spatial neglect and impaired visuospatial working memory, and her reading and writing abilities were affected as well. The third case was reported by Alves et al[31] and involved a 57-year-old man who presented with progressive decline of visuospatial and perceptive abilities, with praxic deficits and also impairment in written language. An early-stage visual variant of AD had been diagnosed 2 years earlier in this patient, following difficulties in driving, writing and reading. As it can be inferred, for these three patients, difficulties were predominantly visual, whereas memory and executive abilities were comparatively more preserved in agreement with previous descriptions[5].

Indeed, there were many similarities between those three patients. They shared a common semiology of occipitoparietal dorsal visual pathway conjugated with visual agnosia due to a disturbance of the occipitotemporal ventral visual pathway and also a relative preservation of cognitive performance without major executive functions disorder or memory impairment. For patients SS and LO (see below), the beginning of their clinical history was marked by various ophthalmological consultations before consulting neurologists. All three had preserved awareness of their disorders, likely responsible for some of the anxiety, as it is often described in PCA subjects[2,22,40].

SS, Roca’s patient[32], received a cognitive intervention whose goals were selected in collaboration with the patient and his family. They aimed to improve the functioning of activities in daily life which they had considered important, such as being able to find nearby objects, diminishing difficulties in pouring drinks and being able to read messages left by his family. The cognitive rehabilitation program contained psycho-educative intervention, cognitive rehabilitation selected to reinforce preserved functions (e.g., recognition of objects and visual exploration strategies) and also compensatory intervention (e.g., use of tactile afferents to offset some visual problematic situations, like pouring a liquid in a glass). Weill-Chounlamountry’s patient, LO, benefited from similar interventions in a multidisciplinary approach (speech therapy, occupational therapy and physiotherapy) in terms of reinforcement of residual visual abilities and compensation strategies; the patient also received psycho-educative intervention[25]. The reinforcement of residual visual abilities contained training of visual recognition (objects, pictures and scenes) and of visual exploration (where to look and how to explore in various tasks, with light pursuit as an example), with the additional aim of decreasing simultagnosia. One of the major complaints of LO was the loss of reading, which was regained once the simultagnosia and inabilities in visual exploration decreased. In addition, compensation strategies were also used in those exercises, such as the use of a rule and “finger-cursor” in order to guide the visual exploration when reading or sewing back-labels on the clothes of the patient to recover autonomy of dressing. Further activities have been conducted to provide a more comprehensive intervention and transfer of training to daily life, such as using public transport as well as planning and organizing projects. Similarly, Alves et al[31] have proposed a cognitive rehabilitation program with specific cognitive training sessions for written language and numbers, temporal and spatial orientation, and promotion of autonomy in daily life; these were complemented by psycho-educative intervention. After an intensive intervention of 3 sessions per week (totaling 60 h), this patient showed small neuropsychological improvements and a modest improvement in daily functioning, with the patient being better able to resort to environmental cues, such as daylight, for temporal orientation.

Psychoeducation

Regarding psycho-educational interventions, Videaud et al[33] proposed use of a psycho-educative program for four patients with PCA and their caregivers. There were six, 2-h sessions given every 2 mo during 1 year. The program included, in order of the sessions: (1) information about the disease to enhance the understanding of PCA subjects and their caregivers; (2) an assessment of repercussion of PCA on the activities of daily life; (3) a speaking time; (4) a use of technical aids to improve the quality of life; and (5) strengthening the knowledge and information about available help (financial and human aids). After the program, results were generally positive: The quality of life appeared unchanged, but knowledge about the disease and exchanges between participants reduced the anxiety of caregivers.

Motor interventions and vision training

Lastly, to our best knowledge, no studies are available that focus on other non-pharmacological interventions, such as vision therapy supervised by orthoptists or single-component physical therapy, or physical exercise for PCA patients.

CONCLUSION
Summary of findings

Cognitive rehabilitation programs have been successful at partially remediating cognitive impairments and improving functionality in PCA, whereas the contribution of isolated psycho-educative intervention was moderate. Many studies have already shown efficacy of cognitive rehabilitation in brain injury[34,35,41] and a recent study shows that such interventions may benefit people exhibiting initial to moderate dementia[38], as is the case with the three clinical case studies of patients with PCA discussed herein[25,31,32]. Strengthening residual abilities might contribute to decreased errors in daily life and, as profiled above, to enhance the quality of life. Possibly, an awareness of some of their preserved abilities and incitement to use them allowed these patients to regain some autonomy. Following their respective interventions, the patients have thus learned to understand their disease and to develop compensatory strategies (and use them) when they were needed with a consequent improvement of the goals they have set. It is our understanding that cognitive rehabilitation intervention can be beneficial as long the overall cognitive abilities are preserved and may, thus, allow for a transfer to daily life.

Clinical implications for current non-pharmacological care

In light of the aforementioned results, some prerequisites seem to be crucial to reach individual functional goals and focused requests of people with PCA: (1) it appears important to ensure that patients have a sufficient overall cognitive functioning level to follow cognitive rehabilitation[42] and to implement strategies proposed by therapists; and (2) cognitive rehabilitation should be focused on life plans of the patient and should also involve caregivers. A previous study indicated[38] that goal-oriented intervention can be helpful to people with AD, since they are able to identify goals and can provide information about their needs in daily life or in order to reduce memory deficits. In the same way, the definition of functional goals in daily life can be a key to success for cognitive rehabilitation in people with PCA. Subjects must, therefore, have realistic functional goals that are shared with therapists and caregivers and which concern either the activity, or the participation, in improving their quality of life and their environment, as referenced by the ICF.

Therefore, based on our current knowledge, cognitive rehabilitation programs designed for PCA subjects could include the following: (1) a psycho-educative intervention component, with the aim of explaining neurological mechanisms underlying the troubles experienced by the patients and their caregivers; (2) stimulation/maximization/development of preserved abilities, either in activities of daily life and/or in visual situations. Patients with PCA might underuse their residual abilities because there is sometimes a real gap between observed performance and complaints expressed. Patients should learn to reuse their skills that are preserved but underused. Psycho-educative intervention will clarify these residual abilities[33]. One example of such residual ability is the gaze. Spontaneously, patients with PCA stare and do not explore their environment, even though they retain the ability to do so. Through dedicated training of exploration with vanishing cues, patients can relearn how to explore visually, first in constrained situations and limited space (for example, a computer screen), and then transfer these trainings to larger environments (“vanishing cues,” which are defined as facilitating the task being performed with cues that fade gradually until they disappear completely); (3) dedicated, focused and intensive training determined according to the goals shared by the multidisciplinary team, patients with PCA and their families (for example, writing a shopping list and being able to read it); and (4) the use of compensatory strategies for praxic disorders or spatial disorders. A standardized occupational therapy program has been previously shown to produce positive effects in stroke patients[43-45]. It uses strategy control and contains three successive phases: (1) initiation and orientation, which encompasses formulating a plan of action and selecting the correct objects; (2) execution of the selected plan; and (3) control of the result, followed by correction, if necessary. Patients learn actions with verbal aids and they can use the verbalization of the action plan during task performance. For example, cues can be labels on clothes for dressing, or a color card displayed on doors to aid in orientation in the home. The therapist teaches systematic spatial orientation of clothes before dressing, and then uses strategy control (i.e., choice of clothes, orientation of clothes with a verbalization by the patient with PCA, dressing, and finally control if the dressing is performed correctly).

Future directions

In the present work we reviewed the existing data on non-pharmacological interventions for PCA. Although evidence is scarce, preliminary findings do exist for cognitive rehabilitation and psychoeducation, suggesting their potential beneficial role/impact. Moreover, present studies suggest and serve as a proof of concept for their implementation feasibility in PCA patients. These findings support related evidence in the field of dementia. For example, in a recent meta-analysis, Alves et al[39] showed that cognitive intervention might lead to benefits in global cognitive status. Moreover these interventions can be developed to be cost-effective and feasible options for ameliorating cognition, functionality and quality of life and/or to provide relevant experiences[46,47].

As has been observed in the global field of Alzheimer's disease and other dementias[46,48], non-pharmacological approaches might play a pivotal/relevant role within the clear need for complementing pharmacological management of PCA. Further studies assessing the potential of non-pharmacological intervention for PCA must rely on systematic enquiry through solid research design. In this regard, randomized controlled studies are considered the gold standard. A concerted and systematic effort of researchers and practitioners in the field should focus on conducting clinical research with short-term applied/applicable value that would be expected to bring clarification of both scientific and potential clinical value. For example, vision therapy studies could be conducted in order to assess their specific efficacy on the compensation, or even amelioration, of neurovisual impairments of these patients and its potential impact on daily life functionality. Indeed, recent evidence suggests that visual rehabilitation might play a relevant role in the neurorehabilitation field, both in terms of aiming at promoting recovery or compensation, and also based on underlying functional and biological neuroplasticity[49,50]. Similarly, cognitive training might delay/slow cognitive dysfunction progression in early stages and should be explored for this purpose.

Taking into account the current state of the field, we propose the following steps: (1) to conduct group studies for interventions that have thus far showed promising results, such as cognitive rehabilitation. This will also aid in clarifying possible differential effects of each therapy; (2) whenever randomized controlled studies or other group studies are not possible, due to participant number or other constraints, case studies[51] should be used, or quasi-experimental methods (e.g., ABAB designs with statistical methods, such as Significant Change); (3) likewise, case studies can provide a feasible option for exploring the potential role of “experimental” non-pharmacological therapies, such as vision therapy, and efforts should be developed for testing each of the available non-pharmacological therapies; and (4) studies should, therefore, sequentially focus on assessing implementation feasibility, efficacy, cost-effectiveness and differential/compared efficacy for symptoms/difficulties/functionality.

In summary, the current research in the field of dementia suggests that PCA patients show relative preserved insight in the early and moderate stages, and preliminary evidence showing promising effects for non-pharmacological interventions in PCA warrant future research.

Footnotes

Manuscript source: Invited manuscript

Specialty type: Medicine

Country of origin: Portugal

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P- Reviewer: Dunbar GL, Xavier-Elsas P S- Editor: Ji FF L- Editor: Filipodia E- Editor: Zhang FF

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