Case Report Open Access
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2025; 13(27): 108868
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.108868
Ishihara color plates utilized as an assessment for simultanagnosia in posterior cortical atrophy: A case report
Francesco Pellegrini, Department of Ophthalmology, ASFO Pordenone Hospital, Pordenone, Italy, Pordenone 33170, Italy
Alessandra Cuna, Department of Ophthalmology, “De Gironcoli” Hospital, AULSS2 Marca Trevigiana, Conegliano 31100, Italy
Mutali Musa, Department of Optometry, University of Benin, Benin 300283, Nigeria
Mutali Musa, Department of Ophthalmology, Africa Eye Laser Center Ltd, Benin 300211, Nigeria
Fabiana D’Esposito, Imperial College Ophthalmic Research Group Unit, Imperial College, London NW1 5QH, United Kingdom
Fabiana D’Esposito, Caterina Gagliano, Department of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy
Rosa Giglio, Daniele Tognetto, Marco Zeppieri, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34129, Italy
Caterina Gagliano, Mediterranean Foundation, “G.B. Morgagni”, Catania 95100, Italy
Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
ORCID number: Mutali Musa (0000-0001-7486-8361); Fabiana D’Esposito (0000-0002-7938-876X); Daniele Tognetto (0000-0001-7197-7765); Caterina Gagliano (0000-0001-8424-0068); Marco Zeppieri (0000-0003-0999-5545).
Co-first authors: Francesco Pellegrini and Alessandra Cuna.
Co-corresponding authors: Caterina Gagliano and Marco Zeppieri.
Author contributions: Pellegrini F and Cuna A wrote the outline; Pellegrini F, Cuna A, Gagliano C and Zeppieri M performed the research and wrote the manuscript; Gagliano C, Zeppieri M and Musa M assisted in the writing of the draft and final paper; Pellegrini F and Cuna A were responsible for study conception and design; D’Esposito F, Giglio R, Tognetto D, Gagliano C, Musa M and Zeppieri M assisted in the research, writing and editing of the manuscript; Gagliano C and Zeppieri A contributed to the scientific editing; D’Esposito F, Giglio R, Tognetto D, Gagliano C, Musa M and Zeppieri M assisted in the editing of the manuscript, making critical revisions and viewing all versions of the manuscript; All authors provided final approval of the article.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria Della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Received: April 24, 2025
Revised: May 19, 2025
Accepted: June 18, 2025
Published online: September 26, 2025
Processing time: 103 Days and 0.1 Hours

Abstract
BACKGROUND

Simultanagnosia is a neurological disorder that impairs an individual's ability to perceive more than one object at a time visually. While the individual may acknowledge the presence of multiple objects in his field of view, he cannot generally summarize the overall percept.

CASE SUMMARY

We describe a case of simultanagnosia in Posterior Cortical Atrophy, evidenced by the Ishihara color test. A 54-year-old woman complained of reading problems despite normal visual acuity and a structural eye exam. The patient failed to identify any of the Ishihara color plates in either eye despite adequate naming of colors. Automated visual field testing showed a homonymous hemianopia. Structural and functional neuroimaging and cerebrospinal fluid analysis were consistent with posterior cortical atrophy.

CONCLUSION

Simultanagnosia can be tested with the Ishihara pseudoisochromatic plates because the recognition of embedded number patterns in the test requires appreciation of a collection of individual stimuli.

Key Words: Simultanagnosia; Posterior cortical atrophy; Color vision; Benson syndrome; Ishihara color plates; Case report

Core Tip: The Isihara pseudoisochromatic plate is a commonly available non-invasive, subjective test for color vision. The diagnosis of simultanagnosia relies on the subjective responses of the likely sufferer to visual stimuli. Therefore, the Isihara test plates offer a novel way of diagnosing this condition. A knowledge of the response of simultanagnostic patients can potentially guide diagnosis when performing standard color vision testing using Isihara test plates.



INTRODUCTION

The Ishihara test plates is a color-based test to assess color vision status and deficiencies, mostly congenital red-green colorblindness. The subject’s ability to correctly identify numbers on the plates is linked to the ability to visually resolve circles of like hues into a numeral or lines that contrasts with the background, made of different colors. Thus, the test not only requires an intact hue discrimination and color vision but also requires the patient to be able to combine the dots into a distinct figure. In this study, we describe a patient referred for unexplained reading difficulty who failed the Ishihara color test. These results suggested simultanagnosia and the final diagnosis of Posterior Cortical Atrophy (PCA).

Ambiguous near vision complaints without evident ocular abnormalities may be the initial and most significant indicator necessitating further examination for underlying cortical pathology (e.g., Posterior Cortical Atrophy).

CASE PRESENTATION
Chief complaints

A 54-year-old woman was referred for unexplained reading problems for 2 years.

History of present illness

The patient was not taking any medications. She denied smoking and had modest alcohol consumption with meals.

History of past illness

The patient stated that she had no history of past illness.

Personal and family history

Previous ophthalmic and neurologic consultations were unremarkable.

Physical examination

The patient’s visual acuity after refraction was 6/6 in both the right and left eye (OU). Extraocular mobility was smooth and full. The pupils were equal in size, reacted to light and showed no relative afferent pupillary defect. Dilation was performed and ocular health assessed using the slit lamp was normal OU. Reading was difficult with many pauses. She described “getting lost while reading a text”, particularly when moving from line to line. However, comprehension of the text was unaffected. Standard automated Humphrey 30-2 perimetry showed a left homonymous hemianopia denser inferiorly (Figure 1). When color vision was tested, the patient failed to correctly name any numbers on Ishihara color plates, even on the test plate.

Figure 1
Figure 1  Standard automated 30-2 perimetry shows left homonymous hemianopia.
Laboratory examinations

Lumbar puncture was positive for increased total tau protein levels of 1549 pg/mL (normal titer: < 340 pg/mL), tau phosphorylated threonine 181 (p-Tau181) of 256.6 pg/mL (normal titer: < 55 pg/mL) with a reduced amyloid Aβ 42 level of 541 pg/mL (normal titer: 660-1075 pg/mL). A diagnosis of PCA was made and the patient was treated with memantine.

Imaging examinations

Standard automated 30-2 perimetry showed left homonymous hemianopia (Figure 1). However, the patient was able to correctly name individual circle colors, thus excluding color vision deficiency and anomia for colors. The simultanagnosia was also confirmed with the Boston cookie theft picture test. Although brain computerized tomography and magnetic resonance imaging (MRI) were unremarkable, positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) revealed a bilateral hypometabolism of the occipital, temporal, and posterior parietal cortex (Figure 2). This was more severe on the right.

Figure 2
Figure 2 18F-fluorodeoxyglucose positron emission tomography shows hypometabolism bilaterally (arrows), denser on the right. Analysis of amyloid positron emission tomography using 18F-flutemetamol showed abnormal uptake also in the posterior (occipital) cortex, with stronger signal on the right (Figure 3).

Analysis of amyloid PET using 18F-flutemetamol showed abnormal uptake in the posterior (occipital) cortex, which was more severe on the right (Figure 3).

Figure 3
Figure 3  Amyloid 18F-flutemetamol positron emission tomography shows abnormal uptake in the occipital right cortex (arrows).
FINAL DIAGNOSIS

Simultanagnosia.

OUTCOME AND FOLLOW-UP

The patient was scheduled for routine annual multidisciplinary follow-up appointments with neurology and ophthalmology to assess cognitive status, visual function, and the course of posterior cortical atrophy. During these visits, standardized evaluations—comprising neuropsychological examinations, perimetric analysis, and functional imaging—will be conducted to identify small alterations in visual and cognitive performance. The pharmacological treatment with memantine was sustained, accompanied by regular assessments of therapeutic effectiveness and tolerability. As of now, the patient's condition has remained stable, with no documented ill effects or notable decline in visual fields or everyday functioning.

DISCUSSION

In 1988, Benson et al[1] published a report on five patients who presented with significant oculovisual problems with no accompanying evident ophthalmic diagnoses. However, all five showed signs of Balint syndrome (e.g., optic ataxia, simultanagnosia, oculomotor apraxia) and Gerstmann syndrome (acalculia, agraphia, finger agnosia, right-left confusion). They also coined the term PCA because of the prominent posterior cerebral involvement discovered after MRI scans.

Brain tissue analyses later showed that Alzheimer’s disease (AD) was the most common underlying pathology. Following this, other diseases/syndromes such as visual variant of AD and Benson syndrome were suggested.

The presentation and characterization of PCA has been expanded to include progressive dementing conditions characterized by higher visual disorders[2]. PCA is characterized by a chronic reduction in visual processing skills and similar functions served by parietal, occipital, and occipito-temporal regions in various combinations. Although PCA has been recognized for decades, the condition remains difficult to diagnose. The vague nature of the complaint may lead to multiple pairs of ineffective reading spectacles, as was the case for our patient. She presented with typical complaints of PCA, i.e., a progressive, pain-free, reading problem associated with a left homonymous hemianopsia without a corresponding lesion on neuroimaging. While the application of Ishihara pseudoisochromatic color plates to reveal simultanagnosia has already been documented in the literature[1,2]. In this instance, the patient's ambiguous report of near vision impairment without discernible ocular pathology served as the initial clinical indicator necessitating a comprehensive diagnostic evaluation. This underscores the significance of evaluating CNS etiologies in similar clinical situations, such as retrochiasmal visual pathway disease. Consequently, the non-specific yet prevalent ophthalmologic issue in this case (near vision impairment) was instrumental for the final diagnosis.

PCA usually occurs in patients younger than those affected with typical AD. As PCA predominantly affects the parieto-occipital cortex, it is likely that the retrochiasmal visual pathway is involved, leading to a homonymous hemianopic visual field defect in up to 78% of cases[3,4]. Data suggest that the condition more strongly affects the right hemisphere and the parietal cortex more severely than the temporal one, thus possibly explaining the frequent occurrence of left homonymous hemianopic visual field defect, denser inferiorly[5]. Because the dorsal (occipito-parietal) system (the “where” pathway) is most frequently involved, PCA is a cause of complete or incomplete Balint syndrome, Gerstmann syndrome, dressing apraxia, and aphasia.

A complete presentation of Balint or Gerstmann syndrome is rare, yet the most common features are simultanagnosia and acalculia[6]. Simultagnosia refers to the failure to simultaneously perceive multiple visual locations[7]. It is the most frequent deficit in PCA, occurring in 9 out of 10 patients[8]. Tasks relying on visual integration, such as the Boston cookie-theft picture, are used to test for simultanagnosia. Moreover, failure to read the Ishihara pseudoisochromatic plates despite preserved color perception is a conspicuous feature in many patients with simultanagnosia[9,10]. An abnormal Ishihara test result may be the only consistent anomaly in routine visual assessments of PCA patients. It is usually misinterpreted as a color deficit, but it should be noted that the ability to interpret the first (control) plate is not dependent on color vision. Patients with simultanagnosia have problems not in seeing the individual-colored circles in each plate, but in combining them into a complex figure (i.e., the number “hidden” in the plate).

Other color vision impairments in PCA may involve compromised color discrimination, resulting from defective visual integration rather than primary retinal cone failure. These anomalies are generally a consequence of higher-order cortical dysfunction. They are not commonly identified by traditional cone function assessments, like the Farnsworth-Munsell 100 Hue test, unless visual crowding or simultanagnosia impairs task execution. Nonetheless, color nomenclature and basic hue recognition are frequently maintained, as exemplified in our case.

Optical coherence tomography (OCT) of the macula and optic nerve revealed a normal foveal contour and intact retinal nerve fiber layer, thereby excluding maculopathy and optic neuropathy as potential causes of the visual complaints. These data reinforced the suspicion of retrochiasmal pathway involvement. This example highlights the need to evaluate retrochiasmal or cortical etiologies in patients experiencing unexplained near vision difficulties, especially when conventional ophthalmologic assessments (e.g., slit-lamp examination, OCT, and refraction) yield no conclusive results. Near vision impairment, often linked to anterior segment disorders, may occasionally indicate a cortical pathology.

During the initial ophthalmologic examination, the patient had difficulties with reading and close vision skills. Considering the lack of anterior segment or retinal disease and the normal OCT results, perimetry was conducted, which indicated a right homonymous hemianopia. This prompted the evaluation of a central nervous system lesion. Ishihara pseudoisochromatic plates were utilized to investigate potential visual processing abnormalities, during which simultanagnosia was hypothesized due to the patient's failure to detect the complete pattern despite having normal color vision. This observation resulted in the implementation of the Boston Naming Test, followed by a neuropsychological assessment and neuroimaging. Differential diagnosis at that stage included neurodegenerative disorders such as PCA or other CNS disorders, such as cerebrovascular accident, space-occupying lesions affecting the parieto-occipital cortex, etc.

Neuroimaging is paramount in evaluating patients with a potential neurodegenerative disorder, such as PCA[11].

Although structural imaging like MRI, may seem inconspicuous in the initial phases of PCA, functional neuroimaging methods such as FDG-PET and amyloid PET have greater sensitivity[12]. These modalities have demonstrated characteristic metabolic alterations, notably hypometabolism in the parieto-occipital cortex. Recent studies have found emerging structural markers, including cortical thinning and atrophy of the posterior corpus callosum, observed by advanced volumetric MRI; however, these may not be detectable with typical imaging procedures.

CONCLUSION

Ophthalmologists should remember that an abnormal Ishihara test may suggest simultanagnosia and can be mistaken for achromatopsia/dyschromatopsia. In the setting of painless and progressive memory loss, visuospatial abnormalities, or features of the Balint or Gerstmann syndromes, differential diagnosis includes a primary, progressive neurodegenerative disorder. Moreover, difficulty in near vision, a common problem for which the patient presents to the ophthalmologist, may be the first symptom of a progressive neurodegenerative disorder.

Footnotes

Provenance and peer review: Invited article; Externally peer reviewed.

Peer-review model: Single blind

Specialty type: Medicine, research and experimental

Country of origin: Italy

Peer-review report’s classification

Scientific Quality: Grade A, Grade B, Grade C, Grade C

Novelty: Grade B, Grade B, Grade C, Grade C

Creativity or Innovation: Grade B, Grade B, Grade C, Grade C

Scientific Significance: Grade B, Grade B, Grade C, Grade C

P-Reviewer: Abdullah OO; Marini D; Song XZ S-Editor: Liu JH L-Editor: Filipodia P-Editor: Zhang L

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