Terra C, de Mattos ÂZ, Chagas MS, Torres A, Wiltgen D, Souza BM, Perez RM. Impact of multidrug resistance on the management of bacterial infections in cirrhosis. World J Clin Cases 2023; 11(3): 534-544 [PMID: 36793638 DOI: 10.12998/wjcc.v11.i3.534]
Corresponding Author of This Article
Carlos Terra, MD, PhD, Associate Professor, Doctor, Gastroenterology-Liver Unit, State University of Rio de Janeiro, Boulevard 28 Setembro, 77-3rd floor-Vila Isabel, Rio de Janeiro 20551-030, Rio de Janeiro, Brazil. firstname.lastname@example.org
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Impact of multidrug resistance on the management of bacterial infections in cirrhosis
Carlos Terra, Ângelo Zambam de Mattos, Marcelo Souza Chagas, Andre Torres, Denusa Wiltgen, Barbara Muniz Souza, Renata Mello Perez
Carlos Terra, Marcelo Souza Chagas, Andre Torres, Barbara Muniz Souza, Gastroenterology-Liver Unit, State University of Rio de Janeiro, Rio de Janeiro 20551-030, Rio de Janeiro, Brazil
Carlos Terra, Liver Unit, Casa de Saúde São José-Rede Santa Catarina, Rio de Janeiro 22271-080, Rio de Janeiro, Brazil
Carlos Terra, Ângelo Zambam de Mattos, Marcelo Souza Chagas, Andre Torres, Denusa Wiltgen, Barbara Muniz Souza, Renata Mello Perez, Alliance of Brazilian Centers for Cirrhosis Car, The ABC Group, Rio de Janeiro 20551-030, Rio de Janeiro, Brazil
Carlos Terra, Liver Unit, Federal Hospital of Lagoa, Rio de Janeiro 22470-050, Rio de Janeiro, Brazil
Ângelo Zambam de Mattos, Graduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90020-090, Rio Grande do Sul, Brazil
Ângelo Zambam de Mattos, Gastroenterology and Hepatology Unit, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 90020-090, Rio Grande do Sul, Brazil
Marcelo Souza Chagas, Internal Medicine, Federal Hospital of Lagoa, Rio de Janeiro 22470-050, Rio de Janeiro, Brazil
Denusa Wiltgen, Department of Internal Medicine, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90020-090, Brazil
Renata Mello Perez, Hepatology Division, Federal University of Rio de Janeiro, Rio de Janeiro 21941-617, Rio de Janeiro, Brazil
Renata Mello Perez, IDOR, D’Or Institute for Research and Education, Rio de Janeiro 22281-100, Rio de Janeiro, Brazil
Author contributions: Terra C, de Mattos ÂZ, Chagas MS, Torres A, Wiltgen D, Souza BM, and Perez RM performed the research, analyzed the data, and wrote the manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos Terra, MD, PhD, Associate Professor, Doctor, Gastroenterology-Liver Unit, State University of Rio de Janeiro, Boulevard 28 Setembro, 77-3rd floor-Vila Isabel, Rio de Janeiro 20551-030, Rio de Janeiro, Brazil. email@example.com
Received: November 10, 2022 Peer-review started: November 10, 2022 First decision: November 26, 2022 Revised: December 22, 2022 Accepted: January 5, 2023 Article in press: January 5, 2023 Published online: January 26, 2023
Patients with cirrhosis have an increased risk of infection and differently from other complications, that over the years are improving in their outcomes, infections in cirrhotic patients are still a major cause of hospitalization and death (up to 50% in-hospital mortality). Infections by multidrug-resistant organisms (MDRO) have become a major challenge in the management of cirrhotic patients with significant prognostic and cost-related impact. About one third of cirrhotic patients with bacterial infections is infected with MDR bacteria and their prevalence has increased in recent years. MDR infections have a worse prognosis compared to infections by non-resistant bacteria because they are associated with lower rate of infection resolution. An adequate management of cirrhotic patients with infections caused by MDR bacteria depends on the knowledge of some epidemiological aspects, such as the type of infection (spontaneous bacterial peritonitis, pneumonia, urinary tract infection and spontaneous bacteremia), bacteriological profile of antibiotic resistance at each health care unit and site of infection acquisition (community acquired, healthcare associated or nosocomial). Furthermore, regional variations in the prevalence of MDR infections determine that the choice of empirical antibiotic therapy must be adapted to the local microbiological epidemiology. Antibiotic treatment is the most effective measure to treat infections caused by MDRO. Therefore, optimizing antibiotic prescribing is critical to effectively treat these infections. Identification of risk factors for multidrug resistance is essential to define the best antibiotic treatment strategy in each case and the choice of an effective empirical antibiotic therapy and its early administration is cardinal to reduce mortality. On the other hand, the supply of new agents to treat these infections is very limited. Thus, specific protocols that include preventive measures must be implemented in order to limit the negative impact of this severe complication in cirrhotic patients.
Core Tip: Infections by multidrug-resistant organisms (MDRO) have become a major challenge in the management of cirrhotic patients with significant prognostic and cost-related impact. This review presents the main epidemiological data, clinical impact, risk factors, and the best management of cirrhotic patients infected with MDR bacteria.
Citation: Terra C, de Mattos ÂZ, Chagas MS, Torres A, Wiltgen D, Souza BM, Perez RM. Impact of multidrug resistance on the management of bacterial infections in cirrhosis. World J Clin Cases 2023; 11(3): 534-544
The rising prevalence of multidrug-resistant organisms (MDRO) (resistant at least to one agent in three or more antimicrobial categories), extensively drug-resistant organisms (a resistance profile that compromised at least one agent in all but two or fewer antimicrobial categories), and pan drug-resistant organisms (PDRO) (resistant to all known antimicrobial agents) represents a global threat to human health[1,2]. At same time, active agents against MDRO are limited despite an increase in the availability of novel antibiotics in recent years.
Reports from the United States and Europe estimate a death toll of 29-33 patients each year associated with antimicrobial resistant microorganisms, with a huge attributable healthcare cost[2-5]. The so called “ESKAPE” pathogens [Enterococcus faecium, Staphylococcus aureus (S. aureus), Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae species] are especially worrisome: The acquisition of antimicrobial resistance genes, in association to the classical mechanisms of antimicrobial resistance (inactivation or alteration of the antimicrobial molecule, bacterial target site modifications, reduced antibiotic penetration/accumulation, and the formation of bacterial biofilms), make ESKAPE pathogens challenging to surveillance and subsequent infections difficult to treat. The SKAPE pathogens have developed resistance against almost all antibiotics used in the clinical setting (oxazolidinones, lipopeptides, macrolides, fluoroquinolones, B-lactams, and also to antibiotics that are considered "the last line of defense”, like carbapenems, glycopeptides and polymyxins). Face to the increased burden of disease and death rates due to treatment failure, the Word Health Organization has designated the SKAPE group as “priority organisms” to focus and guide research and development related to new antibiotics.
Over the last years cirrhosis complications are improving their outcomes with new strategies and technologies. However, infections in cirrhotic patients are still a major cause of hospitalization and death (up to 50% in-hospital mortality). Although the reasons for these imbalanced morbidity and mortality are not totally elucidated, MDR infections may play an important role. In a recent multicentric study that assessed the epidemiology of bacterial infections in hospitalized cirrhotic patients, the overall prevalence of MDRO was 34%. Another report concerning critically ill patients with decompensated cirrhosis points to 46% of isolates being MDROs at admissions. Meanwhile, MDRO isolates responsible for infection during intensive care unit stay were at 60%. Different studies confirm the ominous prognosis of cirrhotic patients with infections by MDRO[9,10] (Table 1) Antimicrobial standard prescription for infection in liver cirrhosis doesn’t routinely comprehend the MDRO spectrum. Cirrhosis itself increases the risk for sepsis and septic shock and when associated with an inappropriate choice of empirical antimicrobial treatment may be determinant of a worst outcome.
Table 1 Prevalence and prognosis of multidrug-resistant organisms infections in cirrhosis.
In infection-induced ACLF, the prevalence of MDR strains was significantly higher; severe sepsis (40.7% vs 21.6%), ACLF (72.3% vs 42.0%) and 90-d mortality (48.7% vs 30.7%) were more frequent in infections caused by MDR strains compared to non-MDR strains
MDROs were not significantly different between specific infections in the different European regions; MDROs were more frequently isolated in the ICU (23.8% vs 12.2%) and nosocomial infections (21.3% vs 8.3% and 6.6% in CA and HCA infections, respectively); MDROs were more prevalent in infections causing severe sepsis/shock (30.3% vs 12.2%) or ACLF (20.5% vs 9.4%)
Presence of MDR bacteria in the blood was not associated with in-hospital mortality
ACLF: Acute on chronic liver failure; EU: European Union; EEA: European Economic Area; MDR: Multi-drug resistant; MDRO: Multi drug resistant organism; ICU: Intensive care unit; CA: Community acquired; HCA: Health-care associated; NA: Not available.
In this review, we describe the epidemiology, clinical settings and the current evidence-based strategies for early recognition and treatment alternatives for MDR infection in cirrhotic patients.
Bacterial infections affect 25%-35% of hospitalized patients with cirrhosis and lead to a four-fold increase in their mortality when compared to noninfected counterparts. The prognostic impact of infections is such that they are considered defining events of state 6 (end-state, late decompensation) in the clinical course of cirrhosis. Moreover, infections (together with alcoholic hepatitis) are the most important drivers of acute decompensation of cirrhosis and acute-on-chronic liver failure (ACLF)[9,13,14].
Despite the evolution in medical care, there is evidence suggesting that mortality associated with infections in individuals with cirrhosis might be increasing. Our group, for instance, has demonstrated that mortality associated with spontaneous bacterial peritonitis increased from 22% to 40% in a decade[15,16]. An explanation for this finding might be the growing importance of infections caused by MDRO. In our setting, after evaluating 5800 isolates from hospitalized patients, we have shown that 38% and 44% of individuals with and without cirrhosis respectively were infected with MDRO. Furthermore, in that study, 20% of Escherichia coli and Klebsiella sp strains infecting patients with cirrhosis were extended-spectrum beta-lactamase (ESBL)-producing bacteria, and 44% of S. aureus strains were methicillin-resistant.
Additionally, a recent European study has clearly demonstrated that infections associated with MDRO are increasing in individuals with cirrhosis. The study evaluated two prospective multicenter cohorts of patients hospitalized for acute decompensation of cirrhosis or ACLF. The first cohort consisted of 1146 individuals evaluated in 2011, of which 39.7% were infected. The second cohort consisted of 883 individuals evaluated in 2018, of which 32.2% were infected. In that study, infections associated with MDRO were diagnosed in 29.2% of subjects with positive cultures in the 2011 cohort and in 37.9% of those pertaining to the 2018 cohort.
On a global level, another prospective cohort study has demonstrated the relevance of infections associated with MDRO in individuals with cirrhosis worldwide. The authors included 1302 infected patients with cirrhosis from 46 different centers in Europe, America and Asia. The most common infections were spontaneous bacterial peritonitis [spontaneous bacterial peritonitis (SBP), 27%], urinary tract infection (22%) and pneumonia (19%), and 57% of isolates consisted of Gram-negative bacteria. Among individuals with positive cultures, 34% were infected with MDRO, most commonly ESBL-producing Enterobacteriaceae, methicillin-resistant S. aureus, vancomycin-resistant Enterococci, Pseudomonas aeruginosa, and Acinetobacter baumannii. The prevalence of infections caused by MDRO was higher in Asia (51%), than in Europe (29%) or America (27%). Independent risk factors for infections with MDRO were being from Asia (and mostly from India, where MDRO were present in 73% of isolates), using antibiotics in the three months previous to hospital admission, being exposed to healthcare facilities, and the site of infection (pneumonia, skin and soft tissue infection and urinary tract infection had higher odds of being caused by MDRO).
Africa and Oceania are poorly represented in studies evaluating the prevalence of MDRO in patients with cirrhosis. However, a recent retrospective cohort study has demonstrated a low prevalence of MDRO in blood cultures of patients with cirrhosis hospitalized in Australia (5.6% of admissions). Despite the low prevalence, the study has shown a significant increase in infections caused by MDRO over a decade, similarly to what had been previously verified in Europe.
PROGNOSTIC IMPACT OF MULTIDRUG RESISTANT BACTERIAL INFECTIONS
Different abnormalities related to the immune system and the occurrence of bacterial translocation from the intestinal lumen increase the susceptibility to infections in cirrhotic patients. Bacterial infections are very common in cirrhosis affecting approximately 1/3 of patients with decompensated cirrhosis and are responsible for significant mortality. In a review study Arvaniti et al evaluated 178 studies with more than 11000 patients with cirrhosis and found that infections increase mortality four-fold. In these patients delayed antibiotic treatment and inadequate empirical therapy are independently associated with mortality[20,21].
As stated before, recent studies suggest that about 34% of cirrhotic patients with bacterial infections are infected with MDRO. Infections by MDRO have a worse prognosis because they are associated with lower rate of infection resolution with traditional empirical antibiotic treatment. In the first series (2005-2007) of a Spanish study, failure to antibiotic treatment was higher (30% vs 8%) in MDR infections than in susceptible bacterial infections. In addition, this study found a higher frequency of septic shock (26% vs 10%) and higher hospital mortality rate (25% vs 12%) in MDR infections compared to infections by non-resistant bacteria. An important finding of the second series (2010-2011) of this study was the higher prevalence of MDRO in nosocomial infections (39%) compared to HCA (a type of infection that occurs in patients with a previous contact with a healthcare environment, e.g., hospitalization or short-term admission for at least 2 d in the previous 90 d, residence in a nursing home or a long-term care facility, or chronic hemodialysis) and community-acquired infections (20% and 0%, respectively). Similarly, an intercontinental study evaluated 1302 infected cirrhotic patients and confirmed that infections caused by MDRO were associated with a lower efficacy (40% vs 68%) and a longer duration (12 d[7-18] vs 10 d[7-15]) of empirical antibiotic treatment. Furthermore, patients with bacterial infections by multi-resistant strains had a higher incidence of septic shock (27% vs 13%) and higher in-hospital and 28-d mortality rate (31% vs 21% and 34% vs 22%, respectively). Finally, a meta-analysis on the impact of infections by MDRO on mortality in cirrhosis found a four times increased risk of mortality associated with bacterial resistance compared to non-resistant bacterial infections.
RISK FACTORS FOR MULTIDRUG RESISTANT BACTERIAL INFECTIONS
MDR infection results from an interaction of different risk factors that act synergistically. Although some risk factors have been identified, we still far from completely understand all the mechanisms involved, and there is still much to research in this field. Identifying risk factors for multidrug resistance is essential to define the best antibiotic treatment strategy in each case.
Previous use of antibiotics is a well-known driver for multidrug resistant infection in different clinical settings. A strong association of MDRO with previous antibiotic therapy was also observed in cirrhotic patients. Extended use of broad-spectrum antibiotics and exposure to systemic antibiotics treatment for at least five days, especially in the previous three months, were highlighted as risk factors[7,24]. Prior use of beta-lactam antibiotics is especially important and has been identified as an independent predictor in the multivariate analysis[22,25]. These findings reinforce the importance of the judicious use of antibiotics in preventing MDRO emergence, with avoidance of overuse and early de-escalation strategies.
Another important risk factor for MDR infections is the previous occurrence of infections by resistant bacteria. In the multivariate analysis, infection caused by MDR bacteria in the last 6 mo increases the risk by 2.45 times.
Current or recent contact with the healthcare system is another important risk factor for MDR infections. A strong association between MDR infections and hospital admission has been shown in several studies[10,26,27]. Patients with nosocomial infection, hospitalization for more than 48 h, and those discharged in the last 30 d are at increased risk for MDR infections. In addition, an increased risk has been reported in patients admitted to the intensive care unit. The risk of MDR infections is also related to the duration of hospitalization and the invasiveness of the procedures performed.
Non-hospitalized patients with healthcare-associated (HCA) infections have an intermediate rate (14%-41%) of infections caused by MDRO, which is lower than in nosocomial infections (23%-39%) but higher than that observed in community-acquired infections (0%-16%). Therefore, the risk of MDR infection is directly related to where the infection was acquired (nosocomial or community-acquired)[22,26,28].
Although the association of quinolone prophylaxis with MDR infection was not identified with the use of norfloxacin for six months in a placebo-controlled trial and in an epidemiological study, the prophylactic use of antibiotics has been pointed out as a risk factor for MDR infections in other studies[22,25,30].
The bacteriological profile of antibiotic resistance in each geographic region also influences the risk of multidrug resistance. Patients from India, other Asian centers, and South America had an increased risk of MDR bacteria. The bacteriological profile of antibiotic resistance at each health care unit is also an important point, and this local antibiotic resistance profile should be considered in the estimation of the MDR risk of each patient[7,31].
MDR risk is also related to the site of the infection. For example, MDR infections were more commonly observed in patients with pneumonia, skin and soft tissue infections than in those with SBP or spontaneous bacteremia[7,27].
A higher prevalence of proton pump inhibitors (PPI) use among patients with MDR infection has been reported, suggesting that PPI could be a risk factor for infections caused by MDRO. However, this association still needs to be better explored in further studies.
MDR infections are more commonly observed in patients with worse liver function, however it is difficult to establish whether liver function is an independent risk factor for MDR because patients with more severe liver disease have more frequent hospitalizations and are more exposed to the use of antibiotics. In the study of Piano et al, liver function was not independently associated with MDR infections in the multivariate analysis although patients with MDR infections presented higher Child and MELD-Na scores. Therefore, even if it is not an independent risk factor, MDR infection is often associated with more severe liver disease.
Table 2 shows the main risk factors for MDR infections.
Table 2 Risk factors for multidrug-resistant infection in cirrhosis.
Risk factors for MDR infection in cirrhosis
Prior (3 mo) use of broad-spectrum antibiotics
Prior infection by MDROs (6 mo)
Recent contact with the healthcare system
Site of infection (pneumonia, skin, and soft tissue infections)
Prophylactic use of antibiotics (?)/proton pump inhibitors use?
MDR: Multi-drug resistant; MDRO: Multi drug resistant organism.
Empirical antibiotic therapy
In the early phases of bacterial infections in patients with cirrhosis, typical signs of infection (like fever) may not be present. Bacterial infections can precipitate and/or constitute part of the process of acute decompensation of cirrhosis, and an appropriate work-up for infections (e.g., diagnostic paracentesis; chest X-ray; urinalysis; blood, ascites and urine cultures) should be made in all patients hospitalized for decompensated liver disease.
Optimizing the prescription of antibiotics is cardinal to effectively treat infections, protect patients from harms caused by unnecessary antibiotic use, and combat antibiotic resistance. As the prevalence of MDRO differs throughout the world, the choice of an empirical antibiotic therapy should be tailored to the local microbiological epidemiology, and it should also be influenced by the type of infection (e.g., SBP, urinary tract infection, pneumonia, soft tissue infection), the severity of infection, and the potential risk factors for infections caused by MDRO[32,33] (Table 1).
Effective antibiotics need to be administered as early as possible. In a retrospective cohort study of 126 cirrhotic patients with SBP-associated septic shock, each hour of delay in the appropriate antimicrobial therapy was associated with 1.86 times increase in hospital mortality. In a worldwide study of hospitalized patients with cirrhosis, the administration of adequate empirical antibiotic treatment was found to be an independent and the only potentially modifiable predictor of in-hospital and 28-d mortality.
In the whole Canonic series, MDROs were more prevalent in infections causing severe sepsis/septic shock and/or ACLF and associated to lower resolution rate and higher mortality at 28 d, especially if treated with inadequate empirical antibiotic strategies. A multicenter retrospective study of 865 consecutive patients with a ﬁrst presentation of SBP in Korea pointed that empirical carbapenem treatment was signiﬁcantly associated to lower in-hospital mortality than third-generation cephalosporins of among 314 critically ill patients (CLIF-SOFA scores ≥ 7; 23.1% vs 38.8%; aOR, 0.84; 95%CI, 0.75-0.94; P = 0.002).
In the treatment of HCA infections in an Italian population of cirrhotic patients, with a prevalence of MDRO of 40%-46%, empirical broad-spectrum therapy (imipenem/cilastatin ± vancomycin) signiﬁcantly reduced in-hospital mortality when compared to third generation cephalosporins, particularly in patients with sepsis. It also reduced the rate of treatment failure and length of stay. In a prospective randomized controlled trial (RCT) that enrolled 32 patients with nosocomial SBP, the broad-spectrum antibiotic therapy (meropenem plus daptomycin) was more effective than ceftazidime (86.7% vs 25%, P < 0.001). Furthermore, meropenem plus daptomycin was effective in 90% of nonresponders to ceftazidime. The response to ﬁrst-line treatment was an independent predictor of survival.
The isolation of MDRO in rectal and nasal swabs could also guide empirical antibiotic strategies in cirrhotic patients. In a study of two European cohorts comprising a total of 907 critically ill patients, including 550 patients with cirrhosis, rectal colonization by MDRO was highly prevalent in cirrhotic patients, ranging from 28.7% to 31.1% in intensive care unit admissions, and MDRO carriage increased the short-term risk of subsequent infection by the colonizing organism.
Patients with cirrhosis and severe infections may benefit from therapeutic strategies aimed at optimizing the antibiotics’ pharmacokinetic/pharmacodynamic target. The use of high antibiotic doses within the first 48-72 h after the diagnosis of infection and the continuous or extended infusions of beta-lactams are more likely to achieve and to maintain serum drug levels above the minimum inhibitory concentration compared to standard bolus administration 6. In a secondary analysis of a European prospective multicenter study of patients with cirrhosis and bloodstream infection, the empirical continuous/extended infusion of piperacillin-tazobactam or carbapenems was associated with lower mortality compared to traditional dosing schedules (adjusted hazard ratio, 0.41; 95%CI, 0.110-0.936; P = 0.04), and it was particularly useful in those patients who were critically ill.
After completing 48-72 h of antibiotic therapy, early de-escalation can be considered based on clinical evolution and available antibiotic susceptibility tests. Short-term treatment is another key measure to prevent antibiotic resistance[7,40,41]. In the 1990s, a randomized controlled trial of 100 patients with SBP showed that a short-course (5-d) treatment is as effective as long-course (10-d) therapy and significantly less expensive. In non-SBP infections, the optimal duration of antibiotic therapy has not been established, but data from the general population suggests that a 7-d course is adequate for most infections.
Figure 1 and Table 3 summarizes the management of patients with cirrhosis and bacterial infection.
Figure 1 Suggested algorithm for the management of patients with cirrhosis and bacterial infections.
Table 3 Recommended empirical antibiotic treatment for bacterial infection in cirrhosis.
Type of infection
Nosocomial and HCA infection or sepsis
SBP, spontaneous bacterial empyema and spontaneous bacteremia
Cefotaxime or Amoxicilin/clavulanic acid
Piperacillin/tazobactam or Meropenem ± Vancomycin or Daptomycin or Linezolid1
Fosfomycin or cotrimoxazole
Uncomplicated: Nitrofurantoin or Fosfomycin; if sepsis: Piperacillin/tazobactam or Meropenem ± Glycopeptide
Piperacillin/tazobactam or Meropenem or Ceftazidime + Ciprofloxacin; Glycopeptides or Linezolid1 should be added in patients with risk factors for MRSA2
Skin and soft tissue infections
Amoxicilin/clavulanic acidor ± Clindamycin
Meropenem or Piperacillin/tazobactam + Glycopeptide or Daptomycin or Linezolid1 ± Cindamycin; if necrotizing fascitis: Meropenem + Daptomycin + Clindamycin
1Vancomycin, teicoplanin or daptomycin in areas with a high prevalence Methicillin-resistant Staphylococcus aureus and vancomycin-susceptible enterococci. Vancomycin must be replaced by linezolid in areas with a high prevalence of vancomycin-resistant enterococci.
HCA: Health care associated; MRSA: Methicillin-resistant Staphylococcus aureus; SBP: Spontaneous bacterial peritonitis; UTI: Urinary tract infection.
The emergence and spread of MDRO in cirrhosis require the implementation of measures aimed to prevent its complications. Pharmacological and non-pharmacological strategies are needed, including hand hygiene and barrier precaution, restriction of antibiotic use to high-risk populations, de-escalating antibiotic therapy based on rapid microbiological tests, study of non-antibiotic prophylaxis measures, broad and strict infection control policies, and programs of epidemiological surveillance.
Non-antibiotic drugs with potential benefit on infections in cirrhosis: Although antibiotic treatment is the most effective measure for controlling established MDR infection, other drugs have shown potential benefits in preventing infections in cirrhosis. A lower occurrence of SBP has been demonstrated in patients using non-selective beta-blockers (NSBB). This benefit of NSBB has been related to its potential effect in improving intestinal motility, improving intestinal permeability, and reducing bacterial translocation[44,45]. Statins also seem to have a beneficial effect against bacterial infection that is attributed to its anti-inflammatory and immunomodulatory properties.
Non-pharmacological measures: Non-pharmacological measures are based on preventive strategies and procedures focusing on intestinal colonization with MDRO. The most important preventive measure is the restrictive and judicious antibiotic use since the main driver for the emergence of MDR infections is the widespread use of antibiotics.
The main non-pharmacological measures focus on gut microbiota. A healthy microbiome is essential to prevent colonization and infection by MDRO. Different approaches focusing on the modulation of the intestinal microbiome were studied, such as probiotics, prebiotics/synbiotics dietary regimens, and fecal microbiota transplant (FMT).
Although some studies have shown favorable results with probiotics, there are also negative studies. This controversy is probably related to different probiotics used and the different number and concentration of the species. Further studies are necessary to define the ideal combination, dose, and duration of administration.
FMT involves the safe transfer of exogenous bacterial flora from a healthy donor to another patient, in capsule or liquid formulations. The rationale for using this technique is the central role of the gastrointestinal colonization in the development of MDR infections. It has been demonstrated that colonization by MDRO is associated with increased risk of infection by the colonizing bacteria in the short-term. FMT has the potential effect of promoting MDRO decolonization.
A systematic review with meta-analysis of five studies, with a total number of 52 patients, evaluated whether FMT decolonizes antibiotic-resistant bacteria from the gut of colonized adults. Evidence from this meta-analysis indicates a potential benefit of FMT as a decolonization intervention, with few adverse effects. Despite the low quality of evidence appointed by this meta-analysis, these preliminary results suggest that FMT is a promising approach that deserves further analysis in RCTs.
In cirrhotic patients, a preliminary study of FMT in patients with advanced cirrhosis on lactulose and rifaximin demonstrated that FMT restored antibiotic-associated disruption in microbial diversity and function. The impact of FMT in the reduction of gut microbial antibiotic resistance genes was later reported in two trials: a capsule FMT trial and an enema FMT trial with 20 patients each. This study demonstrated that, despite differences in routes of administration, antibiotic resistance gene abundance was reduced after FMT compared to pre-FMT baseline and non-FMT groups in decompensated cirrhosis.
Another possible approach, although still requiring further studies, is phage therapy. This technique is based on the use of bacteriophages which are viruses that infect bacteria. The bacteriophages replicate inside the bacteria leading to their destruction. It is an old technique that was left aside with the advent of antibiotics, but nowadays it has been considered again as a therapeutic option to face the serious problem of antibiotic multidrug resistance[51,52]. Although specific studies in cirrhotic patients are not available, phage therapy represents a possible future alternative therapy for controlling MDRO.
In this review, we describe the epidemiology, clinical settings and the current evidence-based strategies for early recognition and treatment alternatives for MDR infection in cirrhotic patients.
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