Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report

Figure 1 Electroencephalography results. A: First visit; B: After treatment with levetiracetam for 4 mo; C: After combined treatment with levetiracetam and melatonin for 7 mo.

Figure 2 Pedigree of family and sequencing results of the pathogenic variant in the melanocortin receptor 4 gene. A: Pedigree of family with pathogenic variant in the melanocortin receptor 4 (MC4R) gene; B: Gene variant site. Chromatogram generated by Sanger sequencing (MC4R) c.494G>A (p.Arg165Gln); heterozygous variation, paternal.

Figure 3  Chart showing melatonin concentration rhythms.