Therapy-related acute promyelocytic leukemia with FMS-like tyrosine kinase 3-internal tandem duplication mutation in solitary bone plasmacytoma: A case report

Figure 1 Microscopic examination of peripheral blood and bone marrow. A: PB showed rouleaux formation of red blood cells and an atypical promyelocyte; B: BM aspiration smears showed increased number of atypical promyelocytes with bilobed nuclei and densely packed large granules in the cytoplasm (Wright-Giemsa staining, × 1000). PB: Peripheral blood; BM: Bone marrow.

Figure 2 Flow cytometric immunophenotyping showing that the bone marrow expressed CD13, CD33, CD117, CD56, CD81, and myeloperoxidase; partially expressed CD38 and CD34; and slightly expressed CD15, CD11b, and CD16.

Figure 3 Cytogenetic analysis. G-band karyotyping of bone marrow cells revealed 46, XX, t(15; 17) (q22; q21).

Figure 4 Sanger sequencing results indicating a positive FMS-like tyrosine kinase 3-internal tandem duplication mutation (the orange arrow indicates the mutation site).