Cholestatic liver diseases: An era of emerging therapies

doi:10.12998/wjcc.v7.i13.1571

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jul 6, 2019; 7(13): 1571-1581
Published online Jul 6, 2019. doi: 10.12998/wjcc.v7.i13.1571

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Figure 1 Overview of bile acid transport system. Na+/ taurocholate cotransporter, organic anion transporters, Bile-salt export pump multidrug export pump MDR1, organic solute transporter OSTa/b, cystic fibrosis transmembrane conductance regulator, apical Na+-dependent bile-salt transporter apical sodium-dependent bile-salt transporter. NTCP: sodium taurocholate co-transporting polypeptide; OATPs: Organic anion transporters; BSEP: Bile-salt export pump; CFTR: Cystic fibrosis transmembrane conductance regulator; OST: Organic solute transporter; ASBT: Apical sodium-dependent bile-salt transporter.

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Figure 2 Mechanism of action of Farnesoid X receptor ligands. FXR: Farnesoid X receptor; OCA: Obetocholic acid; BA: Bile acid; FGF: Fibroblast growth factor; OST: Organic solute transporter; BSEP: Bile-salt export pump.

Citation: Samant H, Manatsathit W, Dies D, Shokouh-Amiri H, Zibari G, Boktor M, Alexander JS. Cholestatic liver diseases: An era of emerging therapies. World J Clin Cases 2019; 7(13): 1571-1581
URL: https://www.wjgnet.com/2307-8960/full/v7/i13/1571.htm
DOI: https://dx.doi.org/10.12998/wjcc.v7.i13.1571