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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2021; 9(35): 10999-11006
Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10999
Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10999
Immunoglobulin G4-related lymph node disease with an orbital mass mimicking Castleman disease: A case report
Feng-Yun Hao, Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Feng-Xia Yang, Department of Abdominal Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Hai-Yan Bian, Xia Zhao, Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Author contributions: Hao FY contributed to the conception of the article and the analysis of pathological data; Yang FX helped with the revision of the article; Bian HY helped to write the manuscript; Zhao X contributed significantly to analysis and manuscript preparation.
Supported by This work was supported by the China Postdoctoral Science Foundation , No. 2020M682128 ; and the Youth Foundation of The Affiliated Hospital of Qingdao University , No. 3052 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xia Zhao, MD, Associate Chief Physician, Department of Hematology, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Huangdao District, Qingdao 266000, Shandong Province, China. alice-xia@163.com
Received: June 20, 2021
Peer-review started: June 20, 2021
First decision: July 16, 2021
Revised: July 25, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: December 16, 2021
Peer-review started: June 20, 2021
First decision: July 16, 2021
Revised: July 25, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: December 16, 2021
Core Tip
Core Tip: Immunoglobulin (Ig) G4-related disease is a group of systemic immune diseases. There is no unified standard for the differentiation of IgG4-related disease from plasma cell Castleman disease. These diseases are sometimes difficult to distinguish from one another. We reported a case of IgG4-related lymph node disease with an orbital mass mimicking Castleman disease. The pathological morphology was similar to Castleman disease, which may lead to misdiagnosis. This case suggested that it is necessary to proceed cautiously in clinical practice with such patients, and immunoglobulin, complement, interleukin-6, C-reactive protein, and other examinations should be performed to confirm the diagnosis.