Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2021; 9(32): 10018-10023
Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.10018
Rare mutation in MKRN3 in two twin sisters with central precocious puberty: Two case reports
Li-Qiong Jiang, Yan-Qiong Zhou, Ke Yuan, Jian-Fang Zhu, Yan-Lan Fang, Chun-Lin Wang
Li-Qiong Jiang, Yan-Qiong Zhou, Ke Yuan, Jian-Fang Zhu, Yan-Lan Fang, Chun-Lin Wang, Department of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Jiang LQ and Wang CL conceived and designed the study; Jiang LQ, Zhou YQ, Yuan K performed the experiments; Jiang LQ and Zhou YQ provided clinical research; Jiang LQ wrote the paper; Jiang LQ, Yuan K, Zhu JF, Fang YL and Wang CL reviewed and edited the manuscript; and all authors read and approved the manuscript.
Supported by the key Research and Development Program of Zhejiang Province (No. 2020C03121).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Lin Wang, MD, PhD, Chief Doctor, Department of Pediatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. hzwangcl@zju.edu.cn
Received: July 1, 2021
Peer-review started: July 1, 2021
First decision: July 16, 2021
Revised: July 21, 2021
Accepted: September 10, 2021
Article in press: September 10, 2021
Published online: November 16, 2021
Core Tip

Core Tip: This report discusses the diagnosis and treatment of central precocious puberty caused by a new Makorin ring finger protein 3 gene mutation and includes a detailed clinical and laboratory analysis of the pathogenic principle, which provided the diagnosis and led to the treatment of central precocious puberty.