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World J Clin Cases. Aug 16, 2021; 9(23): 6639-6653
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6639
Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection
Xin-He Zhang, Die Huang, Yi-Ling Li, Bing Chang
Xin-He Zhang, Die Huang, Yi-Ling Li, Bing Chang, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Chang B designed the study; Zhang XH and Huang D wrote the first draft; Zhang XH, Li YL, and Chang B reviewed and edited the manuscript; all authors read, revised, and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Chang, PhD, Assistant Professor, Department of Gastroenterology, The First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: April 5, 2021
Revised: April 17, 2021
Accepted: July 2, 2021
Article in press: July 2, 2021
Published online: August 16, 2021
Core Tip

Core Tip: The increase in immunoglobulin G4 (IgG4) caused by Clonorchis sinensis infection is rare and there are few reports about the relevant mechanism. We report several novel mechanisms of IgG4 elevation due to Clonorchis sinensis infection to provide more experience and a theoretical basis for clinical diagnosis and treatment of this infection.