Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2021; 9(18): 4728-4733
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4728
Botulinum toxin injection for Cockayne syndrome with muscle spasticity over bilateral lower limbs: A case report
Lin-Chieh Hsu, Po-Ying Chiang, Wei-Pin Lin, Yao-Hong Guo, Pei-Chun Hsieh, Ta-Shen Kuan, Wei-Chih Lien, Yu-Ching Lin
Lin-Chieh Hsu, Po-Ying Chiang, Wei-Pin Lin, Yao-Hong Guo, Pei-Chun Hsieh, Ta-Shen Kuan, Wei-Chih Lien, Yu-Ching Lin, Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Ta-Shen Kuan, Yu-Ching Lin, Department of Physical Medicine and Rehabilitation, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Yu-Ching Lin, Medical Device Innovation Center, National Cheng Kung University, Tainan 704, Taiwan
Author contributions: Hsu LC and Chiang PY collected the medical history, performed the physical examination, and image data from the patient and wrote the main content of the manuscript; Lin WP, Guo YH, Hsieh PC, Kuan TS and Lien WC were involved in the manuscript writing and revision; Lin YC provided guidance on writing and revision of the manuscript; Hsu LC and Chiang PY contributed equally to the manuscript.
Informed consent statement: Informed consent was obtained from the patient and her parents.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Ching Lin, MD, MSc, Associate Professor, Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No. 138 Sheng-li Road, North District, Tainan 704, Taiwan. yuchinglin2011@gmail.com
Received: September 30, 2020
Peer-review started: September 30, 2020
First decision: December 13, 2020
Revised: December 16, 2020
Accepted: February 1, 2021
Article in press: February 1, 2021
Published online: June 26, 2021
Core Tip

Core Tip: Cockayne syndrome (CS) is a rare inherited disease, and symptoms such as spasticity in CS are uncommon. No studies in the literature have addressed the effect of botulinum toxin injection in managing gait problems and spasticity in patients with CS. In this article, we report a patient aged 6 years and 9 mo with CS who responded well to botulinum toxin type A administration.