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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2020; 8(7): 1257-1264
Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1257
Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1257
CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review
Lin Yang, Li Liu, Lei Guo, Jian-Ming Ying, Su-Sheng Shi, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Hua Liang, Department of Medical Oncology, Qingdao Central Hospital, Qingdao 266042, Shandong Province, China
Xing-Sheng Hu, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Yang L and Liang H contributed equally to this research. Hu X and Shi S contributed to the conception of the study; Yang L and Liang H collected the clinical data; Liu L and Guo L reviewed the literature; Yang L, Liang H, Liu L, and Ying JM participated in the preparation of the manuscript; Hu XS and Shi SS contributed to the revision of the manuscript; all authors approved the version to be submitted.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xing-Sheng Hu, MD, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuannanli, Chaoyang District, Beijing 100021, China. huxingsheng66@163.com
Received: December 25, 2019
Peer-review started: December 25, 2019
First decision: February 20, 2020
Revised: February 24, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 6, 2020
Peer-review started: December 25, 2019
First decision: February 20, 2020
Revised: February 24, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 6, 2020
Core Tip
Core tip: Primary lung lymphoepithelioma-like carcinoma (LELC) is a rare type of lung carcinoma without established international diagnostic criteria. For this reason, misdiagnosis may occasionally occur and differential diagnosis with other lung primary carcinomas is required. Herein, we report a 51-year old man with CD56-positive lung LELC, which should be differentiated from large cell neuroendocrine carcinoma. A total of 458 cases of lung LELC have been reported in the literature. This case is the second documented case of CD56-positive lung LELC. The mechanism and potential role of CD56 expression in lung LELC require further investigation.