Vergara-Fernandez O, Trejo-Avila M, Salgado-Nesme N. Sarcopenia in patients with colorectal cancer: A comprehensive review. World J Clin Cases 2020; 8(7): 1188-1202 [PMID: 32337193 DOI: 10.12998/wjcc.v8.i7.1188]
Corresponding Author of This Article
Mario Trejo-Avila, MD, Surgeon, Department of Colorectal Surgery, Instituto Nacional de Ciencias Medicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga, 15, Sección XVI, Mexico 14080, Mexico. mario.trejo.avila@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2020; 8(7): 1188-1202 Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1188
Sarcopenia in patients with colorectal cancer: A comprehensive review
Omar Vergara-Fernandez, Mario Trejo-Avila, Noel Salgado-Nesme
Omar Vergara-Fernandez, Mario Trejo-Avila, Noel Salgado-Nesme, Department of Colorectal Surgery, Instituto Nacional de Ciencias Medicas y Nutrición “Salvador Zubirán”, Mexico 14080, Mexico
Author contributions: Vergara-Fernández O, Trejo-Avila M, and Salgado-Nesme N contributed to design this work, collect and interpret the data, study concept, critically revised the manuscript, and performed overall supervision; all authors contributed to the final approval of the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest related to this article. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mario Trejo-Avila, MD, Surgeon, Department of Colorectal Surgery, Instituto Nacional de Ciencias Medicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga, 15, Sección XVI, Mexico 14080, Mexico. mario.trejo.avila@gmail.com
Received: December 20, 2019 Peer-review started: December 20, 2019 First decision: February 18, 2020 Revised: March 6, 2020 Accepted: March 14, 2020 Article in press: March 14, 2020 Published online: April 6, 2020
Core Tip
Core tip: The prevalence of sarcopenia in patients with colorectal cancer ranges between 12%-60%. The diagnosis of sarcopenia is established by the presence of low muscle quantity or quality (muscle strength, muscle quantity and physical performance). Sarcopenia may negatively impact on the postoperative outcomes of patients with colorectal cancer undergoing surgery. Sarcopenia may also negatively impact on overall survival, disease-free survival, recurrence-free survival, and cancer-specific survival in patients with colorectal cancer. Furthermore, patients with sarcopenia seem prone to toxic effects during chemotherapy. A multimodal approach including nutritional support, exercise programs and anabolic-orexigenic agents, could contribute to muscle mass preservation.
