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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2020; 8(23): 5844-5851
Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.5844
Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.5844
What is the gut feeling telling us about physical activity in colorectal carcinogenesis?
Maja Cigrovski Berkovic, Department for Endocrinology, Diabetes and Metabolism, Clinical Hospital Dubrava, Zagreb 10000, Croatia
Maja Cigrovski Berkovic, Vjekoslav Cigrovski, Faculty of Kinesiology, University of Zagreb, Zagreb 10000, Croatia
Ines Bilic-Curcic, Department of Pharmacology, Faculty of Medicine, J J Strossmayer University Osijek, Osijek 31000, Croatia
Anna Mrzljak, Department of Medicine, Merkur University Hospital, Zagreb 10000, Croatia
Anna Mrzljak, Department of Medicine, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Author contributions: Cigrovski Berkovic M, Cigrovski V, Bilic-Curcic I and Mrzljak A wrote the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anna Mrzljak, MD, PhD, Associate Professor, Department of Medicine, Merkur University Hospital, Zajceva 19, Zagreb 10000, Croatia. anna.mrzljak@mef.hr
Received: August 7, 2020
Peer-review started: August 7, 2020
First decision: September 24, 2020
Revised: September 28, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: December 6, 2020
Peer-review started: August 7, 2020
First decision: September 24, 2020
Revised: September 28, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: December 6, 2020
Core Tip
Core Tip: Sedentary lifestyle is linked to the development of colorectal cancer (CRC); each 2-h increase in sitting time increases the risk of CRC development by 8%. Additionally, engaging in physical activity can prevent 15% of CRC, and by replacing 30 min of sedentary time with physical activity (either light or moderate-vigorous), cancer mortality can be reduced by 8% and 31%, respectively. Although the mechanisms of preventive and favorable effects of physical activity on CRC are still unknown, the most plausible are the influence on chronic inflammation and insulin resistance, with a positive effect on insulin growth factor 1 signaling pathways.