Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3284-3290
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3284
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3284
Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report
Nan Li, Yi-Zhuo Wang, Yi Zhang, Wei-Ling Zhang, Yan Zhou, Dong-Sheng Huang, Pediatric Department, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100176, China
Author contributions: Li N collected and organized the data, and conceived and wrote the article; Wang YZ and Zhang Y did case analysis and revision of the paper; Zhang WL reviewed the article; Zhou Y collected the clinical data; Huang DS reviewed and consented of the article; all authors issued final approval for the version to be submitted.
Supported by the Beijing Hospital Authority "DengFeng" Talent Training Plan , No. DFL20180201 .
Informed consent statement: Informed written consent was obtained from the patient’s guardian
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong-Sheng Huang, PhD, Chief Doctor, Professor, Pediatric Department, Beijing Tongren Hospital Affiliated to Capital Medical University, No. 2 Xihuan South Road, Beijing Economic and Technological Development Zone, Beijing 100176, China. hds5180@sina.com
Received: December 25, 2019
Peer-review started: December 25, 2019
First decision: March 27, 2020
Revised: May 15, 2020
Accepted: July 22, 2020
Article in press: July 22, 2020
Published online: August 6, 2020
Peer-review started: December 25, 2019
First decision: March 27, 2020
Revised: May 15, 2020
Accepted: July 22, 2020
Article in press: July 22, 2020
Published online: August 6, 2020
Core Tip
Core tip: Natural killer/T-cell lymphoma (NKTL) is rare to see with the eyelid site onset and intracranial infiltration, which increases the difficulty of diagnosis and suggests a very poor prognosis. We present the case of a 3-year-old boy who was initially misdiagnosed with ocular cellulitis but finally diagnosed with NKTL with ocular involvement, intracranial infiltration, and chronic active Epstein-Barr virus infection. He achieved complete remission through chemotherapy. Ocular involvement and intracranial infiltration are rare in NKTL cases and are associated with a poor prognosis, but the boy responded well to chemotherapy, which deserves further study and discussion.