Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3230-3239
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3230
Colorectal adenocarcinoma patients with M1a diseases gain more clinical benefits from palliative primary tumor resection than those with M1b diseases: A propensity score matching analysis
Cheng-Lin Li, De-Rong Tang, Jian Ji, Bao Zang, Chen Chen, Jian-Qiang Zhao
Cheng-Lin Li, De-Rong Tang, Jian Ji, Bao Zang, Chen Chen, Jian-Qiang Zhao, Department of Thoracic Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian 223300, Jiangsu Province, China
Author contributions: Li CL and Zhao JQ designed the research and critically revised the manuscript for important intellectual content; all authors performed the research, analyzed the data, and wrote the paper.
Institutional review board statement: The study was approved by the Bioethics Committee of the Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, China.
Informed consent statement: All patients from the SEER database have agreed to participate in scientific research.
Conflict-of-interest statement: All authors declare no competing financial interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jian-Qiang Zhao, MD, Doctor, Department of Thoracic Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, No. 1 West Huanghe Road, Huaian 223300, Jiangsu Province, China. shenglee6871@sina.com
Received: January 14, 2020
Peer-review started: January 14, 2020
First decision: April 12, 2020
Revised: April 25, 2020
Accepted: June 29, 2020
Article in press: June 29, 2020
Published online: August 6, 2020
Core Tip

Core tip: The National Comprehensive Cancer Network clinical practice guidelines do not recommend palliative surgery for metastatic colorectal adenocarcinoma (CRA). Using the Surveillance Epidemiology and End Results database, we found that patients with M1a diseases had a significant survival benefit compared to those with M1b diseases and patients with M1a (lung metastasis) got best long-term outcomes with median overall survival prolonged by 15 mo compared with those without surgical treatment. These findings provide further evidence to support the use of palliative surgical procedure to treat metastatic CRA and develop effective individualized treatment strategy.