Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2019; 7(23): 4091-4097
Published online Dec 6, 2019. doi: 10.12998/wjcc.v7.i23.4091
Hydroxyurea-induced cutaneous squamous cell carcinoma: A case report
Yan Xu, Jian Liu
Yan Xu, Jian Liu, Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Both authors added work and value to the manuscript.
Informed consent statement: Informed consent was obtained from the patient prior to the writing of this case report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jian Liu, MD, Chief Physician, Surgeon, Department of Surgical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China. liujianzy@zju.edu.cn
Telephone: +86-571-87236878 Fax: +86-571-87236878
Received: September 21, 2019
Peer-review started: September 21, 2019
First decision: October 24, 2019
Revised: November 12, 2019
Accepted: November 15, 2019
Article in press: November 15, 2019
Published online: December 6, 2019
Core Tip

Core tip: Long-term hydroxyurea (HU) therapy is a rare cause of cutaneous squamous cell carcinoma (cSCC). To our knowledge, fewer than 20 cases of HU-related cSCC have been reported. Recognizing patterns of HU-associated cSCC is important for surgeons and dermatologists. Moreover, early diagnosis and evaluation are critical for determining optimal treatment regimens. We review the reported cases of cSCC and discuss the pathogenic mechanisms.