Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2019; 7(2): 137-144
Published online Jan 26, 2019. doi: 10.12998/wjcc.v7.i2.137
Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis
Yong Mei, Li Chen, Peng-Fei Zeng, Ci-Jun Peng, Jun Wang, Wen-Ping Li, Chao Du, Kun Xiong, Kai Leng, Chun-Lin Feng, Ji-Hu Jia
Yong Mei, Peng-Fei Zeng, Jun Wang, Chao Du, Kun Xiong, Kai Leng, Chun-Lin Feng, Ji-Hu Jia, Department of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Li Chen, Diagnostics Laboratory, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Ci-Jun Peng, Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Author contributions: Mei Y and Chen L contributed equally to this work; Mei Y, Chen L, Zeng PF and Peng CJ carried out the studies, participated in study design, and drafted the manuscript; Wang J, Li WP, Du C, Xiong K, Leng K, Feng CL and Jia JH participated in data collection and performed the statistical analyses; All authors read and approved the final manuscript.
Supported by the Guizhou Provincial Department of Health Science and Technology Fund, No. GZWJKJ2014-2-151; the Science and Technology Fund of Guizhou Province, No. QKH LH [2016] 7421; and the Zunyi Science and Technology Research and Development Fund, No. ZSKHS [2016] 06.
Institutional review board statement: The study was approved by the Ethics Committee of the Third Affiliated Hospital of Zunyi Medical University, No. ZSYYLL118.
Informed consent statement: All clinical data were collected with informed consent obtained from study participants.
Conflict-of-interest statement: All authors declare that they have no any conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kai Leng, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Zunyi Medical University, No. 98 Fenghuang Load, Zunyi 563000, Guizhou Province, China. lengkai4757zsyy@163.com
Telephone: +86-851-28923927 Fax: +86-851-28923927
Received: October 4, 2018
Peer-review started: October 4, 2018
First decision: October 18, 2018
Revised: November 22, 2018
Accepted: December 21, 2018
Article in press: December 21, 2018
Published online: January 26, 2019
Core Tip

Core tip: Secondary choledocholithiasis is a common disease in hepatobiliary surgery, and most cases do not have symptoms. Failure of timely diagnosis of choledocholithiasis leads to an increased incidence of postoperative residual stones and related complications. In this study, a total of 829 cholelithiasis patients were included, and the results suggest that an abnormally elevated serum gamma-glutamyltransferase level has an important value in the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis. As a convenient, rapid and inexpensive test, serum gamma-glutamyltransferase levels should be tested in secondary asymptomatic choledocholithiasis routine screening.