Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2155-2164
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2155
Reduced microRNA-451 expression in eutopic endometrium contributes to the pathogenesis of endometriosis
Shan Gao, Shuang Liu, Zi-Ming Gao, Peng Deng, Dan-Bo Wang
Shan Gao, Shuang Liu, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110042, Liaoning Province, China
Zi-Ming Gao, Peng Deng, Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110042, Liaoning Province, China
Dan-Bo Wang, Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, Liaoning Province, China
Author contributions: Gao S performed the majority of the experiments and analyzed the data; Liu S and Deng P performed the molecular investigations; Wang DB conceived and designed the experiments; Gao S and Gao ZM wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of China Medical University.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dan-Bo Wang, MD, Professor, Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No. 44, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. wangdb_cmu@126.com
Telephone: +86-13840265165
Received: May 13, 2019
Peer-review started: May 21, 2019
First decision: July 30, 2019
Revised: August 6, 2019
Accepted: August 20, 2019
Article in press: August 20, 2019
Published online: August 26, 2019
Core Tip

Core tip: Despite the high prevalence of endometriosis (EMs), its etiology is unclear. This study focuses on the expression of miR-451 in patients diagnosed with EMs. We report miR-451 as a novel biomarker of EMs as it is downregulated in the eutopic endometrium. YWHAZ, OSR1, TTN, and CDKN2D were identified as potential target genes of miR-451 that may have important roles in disease pathogenesis. We believe that our study contributes significantly to the literature because it suggests a novel biomarker for EMs that may facilitate the early diagnosis of the disease without the need for invasive methods such as laparoscopic examination.