Gao S, Liu S, Gao ZM, Deng P, Wang DB. Reduced microRNA-451 expression in eutopic endometrium contributes to the pathogenesis of endometriosis. World J Clin Cases 2019; 7(16): 2155-2164 [PMID: 31531311 DOI: 10.12998/wjcc.v7.i16.2155]
Corresponding Author of This Article
Dan-Bo Wang, MD, Professor, Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No. 44, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. wangdb_cmu@126.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2019; 7(16): 2155-2164 Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2155
Reduced microRNA-451 expression in eutopic endometrium contributes to the pathogenesis of endometriosis
Shan Gao, Shuang Liu, Zi-Ming Gao, Peng Deng, Dan-Bo Wang
Shan Gao, Shuang Liu, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110042, Liaoning Province, China
Zi-Ming Gao, Peng Deng, Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110042, Liaoning Province, China
Dan-Bo Wang, Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, Liaoning Province, China
Author contributions: Gao S performed the majority of the experiments and analyzed the data; Liu S and Deng P performed the molecular investigations; Wang DB conceived and designed the experiments; Gao S and Gao ZM wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of China Medical University.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dan-Bo Wang, MD, Professor, Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No. 44, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. wangdb_cmu@126.com
Telephone: +86-13840265165
Received: May 13, 2019 Peer-review started: May 21, 2019 First decision: July 30, 2019 Revised: August 6, 2019 Accepted: August 20, 2019 Article in press: August 20, 2019 Published online: August 26, 2019
ARTICLE HIGHLIGHTS
Research background
Despite the high prevalence of endometriosis (EMs), its etiology is unclear.
Research motivation
MiR-451 acts as a tumor suppressor and is relevant to the poor prognosis of cancers.
Research objectives
To evaluate the expression levels and role of miR-451 in the eutopic endometrium and predict possible targets of miR-451 and related signaling pathways.
Research methods
Quantitative real-time PCR was used to evaluate miR-451 expression. Cell Counting Kit-8 and flow cytometric assays were performed to determine cell proliferation and survival rates.
Research results
MiR-451 was downregulated in the eutopic endometrium and related with EMs cell proliferation and apoptosis. YWHAZ, OSR1, TTN, and CDKN2D were identified as potential target genes of miR-451.
Research conclusions
Reduced miR-451 expression in the eutopic endometrium contributes to the pathogenesis of EMs by promoting cell proliferation and reducing apoptosis.
Research perspectives
MiR-451 is a novel biomarker for EMs. YWHAZ, OSR1, TTN, and CDKN2D are potential target genes of miR-451 and may have key roles in this disease.
