Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2019; 7(1): 109-115
Published online Jan 6, 2019. doi: 10.12998/wjcc.v7.i1.109
Bilateral and symmetric C1-C2 dumbbell ganglioneuromas associated with neurofibromatosis type 1: A case report
Chun-Yu Tan, Jia-Wei Liu, Yi Lin, Xin-Xin Tie, Peng Cheng, Xue Qi, Yue Gao, Zong-Ze Guo
Chun-Yu Tan, Jia-Wei Liu, Yi Lin, Xin-Xin Tie, Peng Cheng, Zong-Ze Guo, Department of Neurosurgery, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Xue Qi, X-ray Department, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Yue Gao, Department of Pathology, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Author contributions: Tan CY and Liu JW contributed equally to this work; Tan CY and Liu JW designed the report; Lin Y, Tie XX, Cheng P, Qi X, Gao Y, and Guo ZZ collected the clinical data of the patient; Tan CY and Liu JW analyzed the data and wrote the paper.
Informed consent statement: The patient involved in this study gave his written informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zong-Ze Guo, MD, PhD, Doctor, Professor, Department of Neurosurgery, The First Hospital of China Medical University, 155 Nanjingbei Street, Heping, Shenyang 110000, Liaoning Province, China. cmuguozongze@hotmail.com
Telephone: +86-24-83283133 Fax: +86-24-83283706
Received: September 4, 2018
Peer-review started: September 4, 2018
First decision: October 12, 2018
Revised: October 25, 2018
Accepted: December 7, 2018
Article in press: December 8, 2018
Published online: January 6, 2019
Core Tip

Core tip: Ganglioneuroma is the final mature form of neuroblastic tumors which mainly involves the posterior mediastinum and the retroperitoneal space. We report a rare case of cervical bilateral dumbbell ganglioneuromas associated with neurofibromatosis type 1. Only five cases have been reported. Due to non-specific symptoms, signs, and radiological images, it is difficult to make a definite diagnosis before postoperative pathology. The prognosis of this tumor is good. Complete resection is the exhaustive treatment. Furthermore, incomplete resection does not increase the risk of progression if tumor residuals are smaller than 2 cm.